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POMT2 Knockout Cell Lines

Gene: POMT2

Official Full Name: protein O-mannosyltransferase 2provided by HGNC

Gene Summary: The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT1 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS).[provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26909 POMT2 Knockout cell line (HeLa) Human POMT2 1:3~1:6 Negative Online Inquiry
KO26910 POMT2 Knockout cell line (HCT 116) Human POMT2 1:2~1:4 Negative Online Inquiry
KO26911 POMT2 Knockout cell line (HEK293) Human POMT2 1:3~1:6 Negative Online Inquiry
KO26912 POMT2 Knockout cell line (A549) Human POMT2 1:3~1:4 Negative Online Inquiry

Background

POMT2 Gene Knockout Cell Lines are specialized cellular systems where the POMT2 gene, a critical component in glycosylation processes involving dystroglycan, has been effectively inactivated through targeted genetic editing techniques. This innovative product enables researchers to investigate the underlying mechanisms associated with glycosylation disorders and their impacts on cellular function, providing unique opportunities for study into various muscular dystrophies and related conditions.

The primary functions of the POMT2 gene are linked to the proper glycosylation of proteins, which is vital for cellular communication and muscle integrity. By deploying these knockout cell lines, scientists can elucidate the pathways affected by the absence of POMT2, allowing for the identification of therapeutic targets and the assessment of potential drug efficacy for conditions such as congenital muscular dystrophy. The mechanism underlying the actions of these cell lines involves both altered glycosylation patterns and downstream signaling cascades, making them invaluable to the field of molecular biology and genetics.

The scientific significance of POMT2 Gene Knockout Cell Lines extends beyond basic research; they are proving beneficial in drug discovery and the development of gene therapies aimed at correcting glycosylation defects. This unique tool addresses a vital gap in research on genetic disorders that have historically been challenging to study due to a lack of suitable models.

Compared to traditional cell lines or patient-derived models, these knockout cell lines offer higher precision in studying specific genetic alterations and their resultant phenotypic expressions. This specificity reduces variability commonly seen in other research models, providing more consistent and meaningful data.

For researchers and clinicians focused on genetic disorders and therapeutic interventions, POMT2 Gene Knockout Cell Lines represent an exceptional resource conducive to advancing understanding and treatment innovation. They embody our commitment at [Your Company Name] to facilitate groundbreaking research through high-quality biological products designed for precision and efficacy. Our expertise in cell line development ensures that customers receive reliable and reproducible tools essential for their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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