Gene: POC1B
Official Full Name: POC1 centriolar protein Bprovided by HGNC
Gene Summary: POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14995 | POC1B Knockout cell line (HeLa) | Human | POC1B | 1:3~1:6 | Negative | Online Inquiry |
KO14996 | POC1B Knockout cell line (HCT 116) | Human | POC1B | 1:2~1:4 | Negative | Online Inquiry |
KO14997 | POC1B Knockout cell line (HEK293) | Human | POC1B | 1:3~1:6 | Negative | Online Inquiry |
KO14998 | POC1B Knockout cell line (A549) | Human | POC1B | 1:3~1:4 | Negative | Online Inquiry |
POC1B Gene Knockout Cell Lines are specifically engineered cellular models that provide unparalleled utility in studying the POC1B gene's function and its involvement in various biological processes. These knockout cell lines have been generated using CRISPR-Cas9 technology, which ensures precise editing of the genome, effectively disabling the POC1B gene and allowing researchers to observe the resultant phenotypic alterations and biochemical pathways affected.
One of the key functions of these cell lines is to facilitate comprehensive investigations into the roles of POC1B in centriolar functions, cell cycle regulation, and potential links to ciliopathies. By providing a controlled environment where the POC1B gene is completely knocked out, researchers can uncover mechanisms of cellular signaling, migration, and proliferation that are particularly relevant in cancer research and developmental biology.
The significance of POC1B Gene Knockout Cell Lines extends into various research and clinical applications, particularly in elucidating the genetic underpinnings of diseases associated with POC1B dysregulation. They are ideal tools for drug discovery, target validation, and the study of genetic interactions, making them invaluable for both basic research and translational studies.
What sets POC1B Gene Knockout Cell Lines apart from alternative knockout models is their superior specificity and reliability. The CRISPR-generated nature ensures minimal off-target effects, providing researchers with confidence in their results. Additionally, these cell lines come with extensive documentation and validation data, ensuring ease of use and reproducibility in experimental settings.
For researchers and clinicians dedicated to advancing the understanding of genetic functions and their implications in health and disease, utilizing POC1B Gene Knockout Cell Lines presents a unique opportunity. Such models are pivotal in accelerating discoveries that inform therapeutic strategies and transformative biomedical research.
Our commitment at [Your Company Name] is to provide high-quality, scientifically validated biological products. With a team of experts dedicated to advancing genetic research, our offerings, including the POC1B Gene Knockout Cell Lines, are designed to support the scientific community in achieving its goals with precision and reliability.
Please note that all services are for research use only. Not intended for any clinical use.
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