Gene: PLEKHM2
Official Full Name: pleckstrin homology and RUN domain containing M2provided by HGNC
Gene Summary: This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29691 | PLEKHM2 Knockout cell line (HeLa) | Human | PLEKHM2 | 1:3~1:6 | Negative | Online Inquiry |
KO29692 | PLEKHM2 Knockout cell line (HCT 116) | Human | PLEKHM2 | 1:2~1:4 | Negative | Online Inquiry |
KO29693 | PLEKHM2 Knockout cell line (HEK293) | Human | PLEKHM2 | 1:3~1:6 | Negative | Online Inquiry |
KO29694 | PLEKHM2 Knockout cell line (A549) | Human | PLEKHM2 | 1:3~1:4 | Negative | Online Inquiry |
The PLEKHM2 Gene Knockout Cell Lines represent a pioneering tool in the study of cellular mechanisms and disease pathology. These cell lines have been genetically modified to disrupt the PLEKHM2 gene, which encodes a protein involved in calcium homeostasis and various cellular signaling pathways. By knocking out this specific gene, researchers are able to elucidate its role in cellular processes such as autophagy, cell proliferation, and intercellular communication, which are crucial for understanding diseases like cancer and neurodegenerative disorders.
The key function of the PLEKHM2 knockout lies in its ability to facilitate the investigation of how loss of this gene influences cellular behavior. Characterized by a marked alteration in signaling and metabolic pathways, these cell lines provide a controlled environment to examine the downstream effects of PLEKHM2 deficiency. This opens doors for researchers to identify compensatory mechanisms within the cell and evaluate potential therapeutic targets.
The scientific importance of PLEKHM2 Gene Knockout Cell Lines extends to both fundamental research and clinical settings. These cell lines can serve as a model for studying the molecular underpinnings of various pathologies, enabling scientists to screen for drugs or interventions that could restore normal function or mitigate disease progression. Their applications can significantly contribute to the development of effective therapies and treatments.
A unique selling point of our PLEKHM2 Gene Knockout Cell Lines is the high efficiency and specificity of the gene editing process, minimizing off-target effects and ensuring the reliability of experimental results. Compared to alternatives that rely on transient knockdown techniques, our stable knockout cell lines provide prolonged and reproducible results, making them invaluable for long-term experimentation and validation.
For researchers and clinicians, these cell lines promise to enhance the understanding of gene function and disease mechanisms, driving innovation in therapeutic development. By leveraging our expertise in genetic engineering and cell line development, our company ensures that each product is built on scientific rigor and tailored to meet the needs of the modern research community. The PLEKHM2 Gene Knockout Cell Lines are not only a significant addition to any laboratory's toolkit but also a stepping stone toward advancing biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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