Gene: PLEKHF1
Official Full Name: pleckstrin homology and FYVE domain containing 1provided by HGNC
Gene Summary: Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in endosome and lysosome. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15066 | PLEKHF1 Knockout cell line (HeLa) | Human | PLEKHF1 | 1:3~1:6 | Negative | Online Inquiry |
KO15067 | PLEKHF1 Knockout cell line (HCT 116) | Human | PLEKHF1 | 1:2~1:4 | Negative | Online Inquiry |
KO15068 | PLEKHF1 Knockout cell line (HEK293) | Human | PLEKHF1 | 1:3~1:6 | Negative | Online Inquiry |
KO15069 | PLEKHF1 Knockout cell line (A549) | Human | PLEKHF1 | 1:3~1:4 | Negative | Online Inquiry |
PLEKHF1 Gene Knockout Cell Lines are a cutting-edge biotechnological product designed to facilitate the study of the PLEKHF1 gene, which plays a crucial role in cellular processes such as cytoskeletal dynamics and intracellular signaling. These cell lines are engineered using CRISPR/Cas9 technology to create precise deletions in the PLEKHF1 gene, allowing researchers to investigate the gene's function by observing the resultant phenotypic changes in vitro.
By disrupting the PLEKHF1 gene, these knockout cell lines enable scientists to elucidate the gene's contribution to various physiological and pathological states. The absence of PLEKHF1 can impact cellular morphology, migration, proliferation, and response to external stimuli, providing a powerful tool for understanding its role in conditions such as cancer, neurodegenerative diseases, and other cellular dysfunctions. Researchers can utilize these models to explore therapeutic interventions, gene expression pathways, and potential compensatory mechanisms in systems lacking PLEKHF1.
What sets our PLEKHF1 Gene Knockout Cell Lines apart is their high specificity and functionality. Unlike traditional methods, which can lead to off-target effects or incomplete knockouts, our cell lines are rigorously validated, ensuring robust genetic alterations with minimal unintended consequences. Additionally, they come with supporting documentation and user-friendly protocols, streamlining the experimental setup while allowing for reproducibility and reliability in results.
For researchers and clinicians alike, these knockout cell lines present an invaluable resource for advancing scientific understanding and conducting meaningful preclinical investigations. With our commitment to quality and precision, backed by years of expertise in genetic engineering and cell line development, we deliver a product that not only meets but exceeds the needs of modern biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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