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PLA2G15 Knockout Cell Lines

Gene: PLA2G15

Official Full Name: phospholipase A2 group XVprovided by HGNC

Gene Summary: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29008 PLA2G15 Knockout cell line (HeLa) Human PLA2G15 1:3~1:6 Negative Online Inquiry
KO29009 PLA2G15 Knockout cell line (HCT 116) Human PLA2G15 1:2~1:4 Negative Online Inquiry
KO29010 PLA2G15 Knockout cell line (HEK293) Human PLA2G15 1:3~1:6 Negative Online Inquiry
KO29011 PLA2G15 Knockout cell line (A549) Human PLA2G15 1:3~1:4 Negative Online Inquiry

Background

PLA2G15 Gene Knockout Cell Lines are genetically engineered cell models designed to specifically disrupt the expression of the phospholipase A2 group 15 (PLA2G15) gene. This gene is implicated in various physiological processes, including inflammation and immune response. By utilizing CRISPR-Cas9 technology, these knockout cell lines provide researchers with a powerful tool to investigate the role of PLA2G15 in cellular signaling pathways, metabolic processes, and its associated biological functions.

The primary function of the PLA2G15 gene knockout cell lines is to facilitate the study of PLA2G15’s mechanistic roles in pathophysiology. The absence of the PLA2G15 protein in these engineered cells allows for the elucidation of its contributions to lipid metabolism and cell membrane dynamics, providing insights into various diseases such as cancer and autoimmune disorders. Researchers can perform comparative studies with wild-type cells to assess changes in cellular behavior, gene expression profiles, and responses to stimuli, aiding in the discovery of therapeutic targets.

Scientifically, PLA2G15 knockout cell lines hold significant value in both research and clinical settings. They are instrumental for drug development, particularly in screening for pharmacological agents that can modulate PLA2G15 activity, thereby paving the way for novel therapeutic strategies. Furthermore, these cell lines can serve as valuable assets in cancer biology studies, enabling the exploration of tumor microenvironments and immune evasion mechanisms.

What sets our PLA2G15 Gene Knockout Cell Lines apart from alternatives is the precision achieved through advanced gene-editing techniques and thorough characterization protocols. These well-validated models exhibit stable genetic modifications, ensuring reproducibility in experimental outcomes—a critical factor in high-stakes research.

Ultimately, this product is a valuable asset for researchers and clinicians who aim to deepen their understanding of complex biological mechanisms and develop innovative treatments. Our company prides itself on our extensive expertise in genetic engineering and cell line development, ensuring that our offerings meet the highest standards of scientific rigor and reliability. With our PLA2G15 Gene Knockout Cell Lines, professionals are empowered to advance their research and clinical pursuits confidently.

Please note that all services are for research use only. Not intended for any clinical use.

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