Gene: PKNOX1
Official Full Name: PBX/knotted 1 homeobox 1provided by HGNC
Gene Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in angiogenesis and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within camera-type eye development; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36061 | PKNOX1 Knockout cell line (HeLa) | Human | PKNOX1 | 1:3~1:6 | Negative | Online Inquiry |
KO36062 | PKNOX1 Knockout cell line (HCT 116) | Human | PKNOX1 | 1:2~1:4 | Negative | Online Inquiry |
KO36063 | PKNOX1 Knockout cell line (HEK293) | Human | PKNOX1 | 1:3~1:6 | Negative | Online Inquiry |
KO36064 | PKNOX1 Knockout cell line (A549) | Human | PKNOX1 | 1:3~1:4 | Negative | Online Inquiry |
PKNOX1 Gene Knockout Cell Lines are specialized cellular models developed to facilitate the study of the PKNOX1 gene's role in various biological processes. By utilizing precise CRISPR-Cas9 gene editing techniques, these cell lines have been engineered to disrupt the expression of the PKNOX1 gene, thereby allowing researchers to investigate its function in cellular mechanisms, developmental biology, and disease pathways. The targeted knockout of PKNOX1 provides a powerful tool for elucidating its contributions to gene regulatory networks, specifically in contexts such as cancer progression and stem cell differentiation.
These cell lines operate through the complete ablation of the PKNOX1 gene, which impacts downstream signaling pathways involved in cell growth and fate decisions. This enables scholars to perform comparative studies between wild-type and knockout cells, revealing insights into how the absence of PKNOX1 alters cellular behavior and pathology. The scientific importance of PKNOX1 Gene Knockout Cell Lines is underscored by their applications in both basic research and translational studies, serving as invaluable models for drug testing, genetic interactions, and understanding gene-environment interactions.
What sets PKNOX1 Gene Knockout Cell Lines apart from alternative models is their unequivocal specificity and reliability in mimicking the biological reality of PKNOX1 deficiency. Unlike traditional knockdown approaches, which may only partially inhibit gene function, knockout lines offer a complete and permanent disruption, ensuring that observed phenotypic changes can be confidently attributed to the gene itself.
For researchers and clinicians, the development of these cell lines translates to increased efficiency in experimental design and enhances the reproducibility of results. Consequently, they serve as an essential resource in the quest to uncover fundamental biological principles and develop targeted therapeutic strategies. Our company prides itself on its expertise in cell line generation and molecular biology, committed to providing high-quality biological products that empower scientists to push the boundaries of discovery in gene function and disease mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
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