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PKD1L2 Knockout Cell Lines

Gene: PKD1L2

Official Full Name: polycystin 1 like 2 (gene/pseudogene)provided by HGNC

Gene Summary: This gene encodes a member of the polycystin protein family. This protein may function as a G-protein-coupled component or regulator of cation channel pores. The long isoform of this protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene is a polymorphic pseudogene in humans. [provided by RefSeq, May 2022]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30774 PKD1L2 Knockout cell line (HeLa) Human PKD1L2 1:3~1:6 Negative Online Inquiry
KO30775 PKD1L2 Knockout cell line (HCT 116) Human PKD1L2 1:2~1:4 Negative Online Inquiry
KO30776 PKD1L2 Knockout cell line (HEK293) Human PKD1L2 1:3~1:6 Negative Online Inquiry
KO30777 PKD1L2 Knockout cell line (A549) Human PKD1L2 1:3~1:4 Negative Online Inquiry

Background

PKD1L2 Gene Knockout Cell Lines are specifically engineered cellular models that have the PKD1L2 gene completely inactivated. This product is vital for studying the physiological and pathological roles of PKD1L2 in cellular contexts, particularly its implications in various diseases and developmental processes. Utilizing CRISPR-Cas9 genome editing technology, these cell lines facilitate the examination of gene function by providing a robust platform where the direct effects of PKD1L2 absence can be observed.

The key function of these cell lines lies in their capability to mimic loss-of-function scenarios found in genetic disorders linked to PKD1L2. Researchers can study alterations in cellular signaling pathways, proliferation, and differentiation, leading to greater insights into conditions such as polycystic kidney disease or various forms of cancer where PKD1L2 may be implicated. The absence of this gene allows for the investigation of compensatory pathways and potential therapeutic targets, making it an invaluable tool in both basic and translational research.

Compared to traditional models that may not accurately reflect the genetic alterations present in human disease, PKD1L2 Gene Knockout Cell Lines offer enhanced specificity and relevance. Additionally, these cell lines are readily available and can be readily maintained in standard laboratory conditions, streamlining experimental workflows and reducing time spent on model establishment.

For researchers and clinicians focused on gene function analysis, drug discovery, or disease modeling, the PKD1L2 Gene Knockout Cell Lines present a unique opportunity to advance their understanding of critical biological processes. By choosing these cell lines, users can leverage a model that not only accelerates research outcomes but also enhances the reproducibility of experimental findings.

Our company prides itself on providing high-quality, well-characterized biological products, and the development of the PKD1L2 Gene Knockout Cell Lines is a testament to our commitment to supporting cutting-edge scientific research and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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