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PITPNM3 Knockout Cell Lines

Gene: PITPNM3

Official Full Name: PITPNM family member 3provided by HGNC

Gene Summary: This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25515 PITPNM3 Knockout cell line (HeLa) Human PITPNM3 1:3~1:6 Negative Online Inquiry
KO25516 PITPNM3 Knockout cell line (HCT 116) Human PITPNM3 1:2~1:4 Negative Online Inquiry

Background

PITPNM3 Gene Knockout Cell Lines represent a groundbreaking advancement in the field of molecular biology and genetic research. These specialized cell lines are characterized by the targeted deletion of the PITPNM3 gene, which encodes a protein involved in various biological processes, including phosphatidylinositol signaling and membrane trafficking. By utilizing CRISPR-Cas9 gene editing technology, these cell lines exhibit a complete knockout of PITPNM3, facilitating in-depth studies into its functional roles and implications in cellular pathways.

The primary function of PITPNM3 revolves around its involvement in lipid metabolism and cellular signaling, impacting processes such as cell growth, differentiation, and migration. By studying PITPNM3 knockout cell lines, researchers can elucidate the molecular mechanisms and downstream effects of this gene on cellular function. This knowledge is essential for better understanding disease mechanisms, particularly in cancer and neurodegenerative conditions where dysregulation of phosphoinositide signaling is implicated.

In research and clinical settings, these knockout cell lines are invaluable tools for scientists aiming to investigate gene function and validate potential drug targets. The specific advantage of PITPNM3 knockout cell lines lies in their precision; they offer an exact model for studying the absence of this gene, contrasting starkly with knockdown methodologies that only reduce expression levels. This results in more reliable data regarding cellular responses and therapeutic efficacy.

Furthermore, the availability of PITPNM3 gene knockout cell lines significantly enhances the capability to conduct high-throughput screening assays, helping researchers identify compounds that may modulate lipid signaling pathways effectively. With the increasing focus on personalized medicine, such tools are essential for developing targeted therapies based on an individual’s genetic makeup.

Our company brings years of expertise in creating innovative biological products tailored to meet the needs of the scientific community. By providing PITPNM3 Gene Knockout Cell Lines, we empower researchers and clinicians to drive forward discoveries that can lead to new therapeutic approaches and improved understanding of complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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