Gene: PITPNB
Official Full Name: phosphatidylinositol transfer protein betaprovided by HGNC
Gene Summary: This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28980 | PITPNB Knockout cell line (HeLa) | Human | PITPNB | 1:3~1:6 | Negative | Online Inquiry |
KO28981 | PITPNB Knockout cell line (HCT 116) | Human | PITPNB | 1:2~1:4 | Negative | Online Inquiry |
KO28982 | PITPNB Knockout cell line (HEK293) | Human | PITPNB | 1:3~1:6 | Negative | Online Inquiry |
KO28983 | PITPNB Knockout cell line (A549) | Human | PITPNB | 1:3~1:4 | Negative | Online Inquiry |
PITPNB Gene Knockout Cell Lines are genetically engineered cell lines in which the phosphatidylinositol transfer protein beta (PITPNB) gene has been deleted or disrupted. This innovative product serves as a powerful tool for researchers seeking to elucidate the role of PITPNB in various cellular processes such as lipid metabolism, signal transduction, and membrane trafficking. By utilizing these knockout cell lines, scientists can gain insights into how PITPNB influences cellular functions and contributes to disease mechanisms, particularly in cancer and neurodegenerative disorders where its dysregulation is observed.
The primary function of PITPNB involves its role in the translocation of phosphoinositides and other lipids between cellular membranes, thus governing crucial signaling pathways. The knockout of PITPNB enables researchers to parse out its specific contributions to cell physiology by providing a controlled environment to observe the resultant phenotypic changes. These insights are invaluable for advancing knowledge in cell biology and developing targeted therapeutic strategies.
The scientific importance of PITPNB Gene Knockout Cell Lines extends into various applications within both research and clinical settings. Their utility spans from investigating fundamental biological processes to potential therapeutic interventions, particularly in drug discovery and testing. Researchers can utilize these models to assess the effects of novel compounds, thereby streamlining the development of targeted treatments aimed at modulating lipid-related pathways.
This product stands apart from alternatives due to its specificity and reliability. Compared to traditional methods of gene targeting, these knockout cell lines offer a more efficient and reproducible means of studying gene function without the variability associated with transient transfection techniques. Additionally, the ease of use and compatibility with high-throughput screening approaches make them an attractive option for laboratories focused on cutting-edge research.
In summary, PITPNB Gene Knockout Cell Lines represent a critical resource for researchers and clinicians, offering unique insights into lipid transport mechanisms and disease pathology. By leveraging our expertise in creating and validating these specialized cell lines, we deliver high-quality products that empower scientific discovery and advance biomedical research initiatives.
Please note that all services are for research use only. Not intended for any clinical use.
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