Gene: PIP4K2C
Official Full Name: phosphatidylinositol-5-phosphate 4-kinase type 2 gammaprovided by HGNC
Gene Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and identical protein binding activity. Involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of insulin receptor signaling pathway; and positive regulation of autophagosome assembly. Located in several cellular components, including autophagosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07855 | PIP4K2C Knockout cell line (HeLa) | Human | PIP4K2C | 1:3~1:6 | Negative | Online Inquiry |
KO07856 | PIP4K2C Knockout cell line (HCT 116) | Human | PIP4K2C | 1:2~1:4 | Negative | Online Inquiry |
KO07857 | PIP4K2C Knockout cell line (HEK293) | Human | PIP4K2C | 1:3~1:6 | Negative | Online Inquiry |
KO07858 | PIP4K2C Knockout cell line (A549) | Human | PIP4K2C | 1:3~1:4 | Negative | Online Inquiry |
PIP4K2C Gene Knockout Cell Lines are genetically modified cellular models in which the PIP4K2C gene has been disrupted through targeted gene-editing techniques, enabling researchers to investigate the functional roles of this gene in various biological processes. PIP4K2C is involved in phosphoinositide metabolism, influencing cellular signaling pathways and lipid signaling, which are critical for cellular growth, survival, and proliferation. By utilizing these knockout cell lines, researchers can effectively study the phenotypic consequences of PIP4K2C loss, allowing for a deeper understanding of its role in cell biology and disease mechanisms.
The primary function of PIP4K2C is to regulate the levels of phosphatidylinositol-5-phosphate (PI5P), a lipid that plays a pivotal role in various cellular processes, including autophagy, apoptosis, and membrane trafficking. Knockout of the PIP4K2C gene leads to altered PI5P levels, thereby impacting signal transduction pathways that guide cell fate decisions and responses to stress. This model is invaluable for exploring therapeutic targets in cancer, neurodegenerative diseases, and metabolic disorders where aberrant lipid signaling is often implicated.
In scientific research and clinical settings, the PIP4K2C Gene Knockout Cell Lines are critical for elucidating the specific functions of phosphoinositides and their interactions with various cellular signaling pathways. Unlike alternative models, our cell lines are rigorously validated for specificity and functionality, ensuring research reliability. They offer a unique opportunity to examine the genetic and biochemical consequences of PIP4K2C loss in a controlled environment, thus providing clarity on its role in various pathologies.
For researchers and clinicians aiming to uncover novel mechanisms of disease or develop targeted therapies, PIP4K2C Gene Knockout Cell Lines represent a powerful tool that empowers cutting-edge scientific investigation. By leveraging our extensive expertise in genetic engineering and our commitment to providing high-quality biological tools, we ensure that our products meet the rigorous demands of modern research. Our offerings not only facilitate innovation in the lab but also support advancements in clinical applications, making them indispensable for today’s scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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