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PINX1 Knockout Cell Lines

Gene: PINX1

Official Full Name: PIN2 (TERF1) interacting telomerase inhibitor 1provided by HGNC

Gene Summary: Enables telomerase RNA binding activity and telomerase inhibitor activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to nucleolus; and protein localization to organelle. Acts upstream of or within telomere maintenance via telomerase. Located in several cellular components, including chromosomal region; nuclear lumen; and spindle. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20407 PINX1 Knockout cell line (HeLa) Human PINX1 1:3~1:6 Negative Online Inquiry
KO20408 PINX1 Knockout cell line (HCT 116) Human PINX1 1:2~1:4 Negative Online Inquiry
KO20409 PINX1 Knockout cell line (A549) Human PINX1 1:3~1:4 Negative Online Inquiry

Background

PINX1 Gene Knockout Cell Lines are a unique genetic tool designed to facilitate advanced research on the PINX1 gene, known for its role in telomere maintenance and cellular aging. These cell lines are engineered to have a complete knockout of the PINX1 gene, enabling scientists to study the resultant phenotypic changes and unravel the molecular mechanisms that underlie cellular processes such as proliferation, apoptosis, and oncogenic activity.

The primary function of PINX1 is to regulate telomere length by modulating the activity of telomerase, thus playing a critical part in maintaining chromosomal integrity. In the absence of PINX1, researchers can observe effects such as telomerase overactivation, premature cellular senescence, and altered cell death pathways. The mechanisms through which PINX1 exerts its effects underscore its significance in cancer research, age-related diseases, and regenerative medicine.

In scientific settings, the applications of PINX1 Gene Knockout Cell Lines extend to drug discovery, genetic studies, and therapeutic development. By providing a model to assess the consequences of PINX1 loss, these cell lines represent an invaluable resource for elucidating the contributions of this gene in various biological and pathological processes.

Compared to other models that require cumbersome gene editing techniques, these ready-to-use knockout cell lines offer significant advantages in experimental design. They enable rapid screening and reduce variability in results, enhancing reproducibility and reliability. Researchers can trust that their investigations are built upon a solid foundation of genetic specificity.

The value of PINX1 Gene Knockout Cell Lines is clear for researchers and clinicians aiming to innovate in the realms of cancer biology, genetics, and therapeutic interventions. Their precise genetic modifications empower users to draw meaningful conclusions, ultimately accelerating the pace of scientific discoveries.

Our company takes pride in its commitment to delivering high-quality biological products, backed by years of expertise in genetic engineering and cell line development. We are dedicated to supporting the scientific community with reliable tools that enhance research capabilities and foster advancements in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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