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PIK3C2A Knockout Cell Lines

Gene: PIK3C2A

Official Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07836 PIK3C2A Knockout cell line (HeLa) Human PIK3C2A 1:3~1:6 Negative Online Inquiry
KO07837 PIK3C2A Knockout cell line (HCT 116) Human PIK3C2A 1:2~1:4 Negative Online Inquiry
KO07838 PIK3C2A Knockout cell line (HEK293) Human PIK3C2A 1:3~1:6 Negative Online Inquiry
KO07839 PIK3C2A Knockout cell line (A549) Human PIK3C2A 1:3~1:4 Negative Online Inquiry

Background

PIK3C2A Gene Knockout Cell Lines are specifically engineered cellular models that feature targeted disruption of the PIK3C2A gene, which encodes a key phosphoinositide 3-kinase (PI3K) enzyme involved in cellular signaling pathways essential for various biological processes, including growth, proliferation, and survival. By employing CRISPR/Cas9 gene editing technology, these cell lines facilitate precise deletion of the PIK3C2A gene, enabling researchers to investigate the functional consequences of its absence in a controlled environment.

The primary function of PIK3C2A involves the synthesis of phosphatidylinositol-3-phosphate (PI3P), which is critical for cellular membrane dynamics and serves as a signaling molecule that influences endosomal trafficking and autophagy. These knockout cell lines enable scientists to elucidate the specific pathways influenced by PIK3C2A, helping to unravel its role in oncogenesis, metabolism, and developmental biology.

The scientific importance of PIK3C2A Gene Knockout Cell Lines is particularly evident in the fields of cancer research and drug discovery. By studying cellular responses to various stimuli or therapeutic agents in the context of PIK3C2A deficiency, researchers can gain insights into potential mechanisms of resistance or novel therapeutic targets. In clinical settings, these cell lines can aid in the development of targeted therapies that enhance treatment efficacy for cancers driven by aberrant PI3K signaling.

One of the unique selling points of our PIK3C2A Gene Knockout Cell Lines is their reliable and reproducible genetic modification, which provides a consistent background for experimental analysis. Unlike other knockout models that may have off-target effects or inconsistent expression patterns, our cell lines are subject to rigorous quality control, ensuring that researchers can obtain accurate and meaningful data.

Investing in PIK3C2A Gene Knockout Cell Lines empowers researchers and clinicians to delve deeper into the intricacies of cellular signaling networks, ultimately contributing to the advancement of biomedical science. With extensive expertise in gene editing and a commitment to delivering high-quality biological products, our company is a trusted partner for researchers striving for breakthroughs in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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