Gene: PIGX
Official Full Name: phosphatidylinositol glycan anchor biosynthesis class Xprovided by HGNC
Gene Summary: This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Studies in rat indicate that the protein is translated from a non-AUG translation initiation site. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15124 | PIGX Knockout cell line (HeLa) | Human | PIGX | 1:3~1:6 | Negative | Online Inquiry |
KO15125 | PIGX Knockout cell line (HCT 116) | Human | PIGX | 1:2~1:4 | Negative | Online Inquiry |
KO15126 | PIGX Knockout cell line (HEK293) | Human | PIGX | 1:3~1:6 | Negative | Online Inquiry |
KO15127 | PIGX Knockout cell line (A549) | Human | PIGX | 1:3~1:4 | Negative | Online Inquiry |
PIGX Gene Knockout Cell Lines represent a pioneering advancement in genetic research, specifically designed to facilitate the exploration of gene function and the elucidation of biological pathways. These cell lines are engineered through the precise deletion of the PIGX gene, which encodes for an essential protein involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis. By removing PIGX, the lines provide a unique platform to study the subsequent impact on cellular processes, particularly those related to cell signaling and membrane dynamics.
The key mechanism at play in PIGX Gene Knockout Cell Lines involves the disruption of GPI anchor formation, leading to an accumulation of proteins that would typically be anchored to the cell membrane. This alteration allows researchers to evaluate changes in cellular behavior, such as adhesion, migration, and signaling pathways, thereby providing valuable insights into disease states, especially in cancer and neurodegenerative disorders.
The scientific importance of these cell lines lies in their application within both fundamental research and clinical contexts. Researchers can leverage PIGX knockout models to investigate disease mechanisms, screen for therapeutic compounds, or assess potential biomarkers for disease progression. Clinicians can find value in translating these findings into targeted therapies or developing innovative diagnostics.
One of the unique selling points of PIGX Gene Knockout Cell Lines is their superior specificity and reproducibility compared to traditional knockdown methods, such as RNA interference. Unlike transient transfection techniques that often result in incomplete gene silencing, these knockout lines facilitate stable and long-term studies, allowing for more reliable results that can be confidently translated into therapeutic strategies.
For researchers and clinicians looking to advance their understanding of GPI-mediated processes, PIGX Gene Knockout Cell Lines offer significant advantages. Their ability to serve as a robust model system underscores their relevance in the developmental and pathological study of human diseases, ultimately driving innovation in therapeutic approaches.
Our company is at the forefront of biotechnological advancements, specializing in the development of high-quality genetic models. With a commitment to excellence and innovation, our offerings empower researchers and clinicians to explore the complexities of genetics with confidence and precision.
Please note that all services are for research use only. Not intended for any clinical use.
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