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PIGT Knockout Cell Lines

Gene: PIGT

Official Full Name: phosphatidylinositol glycan anchor biosynthesis class Tprovided by HGNC

Gene Summary: This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06513 PIGT Knockout cell line (HeLa) Human PIGT 1:3~1:6 Negative Online Inquiry
KO06514 PIGT Knockout cell line (HCT 116) Human PIGT 1:2~1:4 Negative Online Inquiry
KO06515 PIGT Knockout cell line (HEK293) Human PIGT 1:3~1:6 Negative Online Inquiry
KO06516 PIGT Knockout cell line (A549) Human PIGT 1:3~1:4 Negative Online Inquiry

Background

PIGT Gene Knockout Cell Lines represent a significant advancement in cellular biology research, specifically designed to facilitate the study of the PIGT gene and its associated functions. These cell lines are engineered to have specific deletions or disruptions in the PIGT gene, which encodes for a key enzyme involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis—an essential post-translational modification that plays a critical role in cell surface protein localization and function.

The primary function of PIGT in cellular processes is to mediate the synthesis of GPI anchors, enabling the attachment of numerous proteins to the cell membrane. By understanding the repercussions of knocking out the PIGT gene, researchers can elucidate its role in various biological functions, including signal transduction, cell adhesion, and immune response. This targeted approach allows for advancements in understanding diseases linked to faulty GPI anchor biosynthesis, such as certain neurological disorders and cancer.

In both research and clinical settings, the PIGT Gene Knockout Cell Lines provide invaluable tools for studying gene function and characterizing the molecular pathways involved in health and disease. Their application spans drug discovery, genetic pathology, and the development of gene therapies, making them essential for academics and biotech companies alike.

Compared to traditional gene editing methods, our PIGT Gene Knockout Cell Lines offer advantages such as time efficiency and reproducibility, allowing researchers to obtain results faster and with greater consistency. Furthermore, these engineered cell lines are ready-to-use, streamlining experimental workflows and reducing the resources required for generating knockout models.

For researchers and clinicians, utilizing PIGT Gene Knockout Cell Lines translates to more reliable data and impactful discoveries that can lead to innovative therapeutic strategies. Our company prides itself on its commitment to providing high-quality biological products developed with cutting-edge technology and a deep understanding of biological systems. We are dedicated to supporting the scientific community in unlocking the complexities of cellular biology through tailored tools and solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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