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PHF12 Knockout Cell Lines

Gene: PHF12

Official Full Name: PHD finger protein 12provided by HGNC

Gene Summary: Enables phosphatidylinositol binding activity and transcription corepressor activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of Sin3-type complex and transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15187 PHF12 Knockout cell line (HeLa) Human PHF12 1:3~1:6 Negative Online Inquiry
KO15188 PHF12 Knockout cell line (HCT 116) Human PHF12 1:2~1:4 Negative Online Inquiry
KO15189 PHF12 Knockout cell line (HEK293) Human PHF12 1:3~1:6 Negative Online Inquiry
KO15190 PHF12 Knockout cell line (A549) Human PHF12 1:3~1:4 Negative Online Inquiry

Background

PHF12 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate in-depth studies of the PHF12 gene's biological functions, involvement in disease mechanisms, and potential therapeutic targets. These knockout cell lines are generated using CRISPR-Cas9 technology, which allows for specific and precise alteration of the genome, effectively silencing the PHF12 gene in various cellular contexts.

The key functions of PHF12 Gene Knockout Cell Lines lie in their utility to explore gene function and regulation. By completely disrupting the PHF12 gene, researchers can elucidate its roles in cellular processes such as epigenetic regulation, transcriptional control, and differentiation pathways. This understanding is vital for investigating related pathological conditions, including certain cancers and developmental disorders, providing insights that are often unattainable with traditional overexpression or knockdown techniques.

The scientific significance of these cell lines extends to both fundamental research and clinical settings. In academia, they serve as invaluable tools for validating hypotheses regarding gene function, mechanism of action, and interactions with other cellular pathways. Clinically, they are pivotal in drug discovery and development, allowing for the evaluation of therapeutic interventions targeting the PHF12 pathway, and may eventually contribute to personalized medicine approaches by determining patient-specific responses to treatment.

Compared to alternative gene manipulation techniques, PHF12 Gene Knockout Cell Lines offer unparalleled precision and efficiency in confirming gene function and observing phenotypic consequences. Their generation through CRISPR ensures a stable and complete knockout, which is essential for reproducibility and reliability in research outcomes.

For researchers and clinicians, the ability to dissect the role of PHF12 in various biological contexts makes this product essential for advancing the understanding and treatment of significant health challenges. Our company's extensive expertise in the field of genetic engineering and commitment to high-quality products ensures that our PHF12 Gene Knockout Cell Lines are robustly characterized and ready to enhance your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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