Gene: PHC2
Official Full Name: polyhomeotic homolog 2provided by HGNC
Gene Summary: In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38115 | PHC2 Knockout cell line (HeLa) | Human | PHC2 | 1:3~1:6 | Negative | Online Inquiry |
KO38116 | PHC2 Knockout cell line (HCT 116) | Human | PHC2 | 1:2~1:4 | Negative | Online Inquiry |
KO38117 | PHC2 Knockout cell line (HEK293) | Human | PHC2 | 1:3~1:6 | Negative | Online Inquiry |
KO38118 | PHC2 Knockout cell line (A549) | Human | PHC2 | 1:3~1:4 | Negative | Online Inquiry |
PHC2 Gene Knockout Cell Lines are precisely engineered cellular models that facilitate the study of the PHC2 gene's role in various biological processes. Utilizing CRISPR-Cas9 gene-editing technology, these cell lines specifically disable the PHC2 gene, allowing researchers to investigate its function by observing the resultant phenotypic and molecular changes. The knockout approach provides a powerful tool to elucidate gene function, dissect molecular pathways, and identify potential therapeutic targets.
The key mechanism of PHC2 Gene Knockout Cell Lines involves the targeted disruption of the PHC2 locus, which leads to the complete loss of PHC2 protein expression. This ablation allows researchers to analyze the consequences of PHC2 deficiency on cellular physiology, including effects on cell proliferation, differentiation, and response to stimuli. This insight is particularly valuable given PHC2's involvement in critical biological functions such as chromatin remodeling and transcription regulation.
In terms of scientific relevance, these cell lines are indispensable for fundamental research across various domains, including cancer biology, neurobiology, and developmental biology. They enable clinicians and researchers to model diseases associated with PHC2 dysregulation, thus facilitating the discovery of novel interventions. Furthermore, they can be utilized for drug screening and biomarker identification, promoting personalized medicine approaches.
The PHC2 Gene Knockout Cell Lines stand out in the market due to their verified specificity and robustness, compared to conventional knockout methods that may yield off-target effects. Their ease of use and high reproducibility make them an attractive option for both academic researchers and biotech companies. Moreover, their consistent performance enhances the reliability of experimental results, ensuring better translational potential.
For researchers and clinicians aiming to advance their understanding of gene function and its implications in human health, the PHC2 Gene Knockout Cell Lines provide a unique and invaluable resource. Our company prides itself on rigorously developing high-quality biological products, underpinned by extensive scientific expertise and a commitment to supporting advancements in research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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