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PGLYRP1 Knockout Cell Lines

Gene: PGLYRP1

Official Full Name: peptidoglycan recognition protein 1provided by HGNC

Gene Summary: Enables several functions, including Hsp70 protein binding activity; peptidoglycan binding activity; and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium. Located in extracellular exosome. Is active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33668 PGLYRP1 Knockout cell line (HEK293) Human PGLYRP1 1:3~1:6 Negative Online Inquiry

Background

PGLYRP1 Gene Knockout Cell Lines are genetically engineered cell lines designed to lack the PGLYRP1 gene, which encodes the peptidoglycan recognition protein 1. This protein plays a crucial role in the innate immune response, specifically in recognizing bacterial peptidoglycans and initiating appropriate immune reactions. By utilizing these knockout cell lines, researchers can effectively study the specific biological functions associated with PGLYRP1 and gain insights into its involvement in host defense mechanisms against pathogens.

These cell lines function as valuable tools for elucidating the immune pathways activated upon bacterial infection. When the PGLYRP1 is absent, researchers can investigate changes in cellular signaling, cytokine production, and overall immune responses, enabling a deeper understanding of host-pathogen interactions. This can lead to potential therapeutic strategies targeting immune deficiencies or inflammatory diseases linked to altered PGLYRP1 activity.

The scientific importance of PGLYRP1 Gene Knockout Cell Lines extends to multiple research areas, including immunology, microbiology, and pharmacology. They provide a robust model for studying infections, chronic inflammatory conditions, and for evaluating the efficacy of novel therapeutics aimed at modulating immune responses. Their application in clinical research could pave the way for advancements in immunotherapy and personalized medicine.

What sets these cell lines apart from alternative models is their specificity and precision. By precisely eliminating the PGLYRP1 gene, these knockout lines present a clean background for assessing the effects of PGLYRP1 deficiency without the confounding effects of other genes. This level of specificity ensures high-quality data and improved reproducibility in research findings.

For researchers and clinicians, the value of PGLYRP1 Gene Knockout Cell Lines lies in the ability to identify and validate new therapeutic targets and biomarkers essential for advancing the field of immunology and infectious disease. With consistent quality and supported by extensive background research, these lines provide a reliable resource for innovative discoveries.

At [Your Company Name], we pride ourselves on our deep expertise in genetic engineering and commitment to providing cutting-edge biological products that empower researchers in their quest for scientific breakthroughs. Our proficiency in developing precisely characterized cell lines underscores our dedication to excellence in supporting the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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