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PGBD2 Knockout Cell Lines

Gene: PGBD2

Official Full Name: piggyBac transposable element derived 2provided by HGNC

Gene Summary: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15216 PGBD2 Knockout cell line (HeLa) Human PGBD2 1:3~1:6 Negative Online Inquiry
KO15217 PGBD2 Knockout cell line (HCT 116) Human PGBD2 1:2~1:4 Negative Online Inquiry
KO15218 PGBD2 Knockout cell line (HEK293) Human PGBD2 1:3~1:6 Negative Online Inquiry
KO15219 PGBD2 Knockout cell line (A549) Human PGBD2 1:3~1:4 Negative Online Inquiry

Background

PGBD2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate research in gene function and cellular processes related to the PGBD2 (Pogo Transposable Element Derived 2) gene. These cell lines have been engineered through precise gene-editing techniques, such as CRISPR/Cas9, to disable the PGBD2 gene, allowing researchers to investigate the effects of its absence on cellular behavior, proliferation, and differentiation.

Key functions of the PGBD2 Gene Knockout Cell Lines lie in their utility for studying the role of PGBD2 in various biological processes, including transposon activity, genomic stability, and cellular responses to DNA damage. By comparing the knockout lines with wild-type counterparts, scientists can elucidate the gene's contribution to cellular signaling pathways and its potential involvement in disease states, particularly in oncology and developmental biology.

The scientific importance of these cell lines extends to applications in both research and clinical settings. They serve as vital tools for validating gene targets in drug discovery and testing therapeutic mechanisms, particularly for diseases where PGBD2 overexpression has been implicated. Additionally, these models can be utilized to understand the interactions between transposable elements and host genomes, further advancing our knowledge of genetic regulation and evolution.

One of the distinct advantages of PGBD2 Gene Knockout Cell Lines is their precise gene modification, which offers a knockdown effect without the off-target effects often seen in other methods. This specificity ensures reliable and reproducible results critical for experiments, granting researchers confidence in their findings compared to alternative cell lines that may exhibit variable gene expression profiles.

Moreover, these knockout cell lines are readily available for researchers, clinicians, and institutions focused on advancing genetic research and therapeutic developments, making them a valuable asset to any laboratory. By choosing PGBD2 Gene Knockout Cell Lines, users tap into a robust model that offers clarity and insight into the intricate workings of gene function and its implications in health and disease.

Our company specializes in providing high-quality biological products, including tailored gene knockout cell lines, to support the research community in their quest to understand and manipulate genetic materials effectively. Our commitment to excellence is reflected in our precise engineering techniques and adherence to strict scientific standards, ensuring our products help drive discovery and innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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