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PGAP3 Knockout Cell Lines

Gene: PGAP3

Official Full Name: post-GPI attachment to proteins phospholipase 3provided by HGNC

Gene Summary: This gene encodes a glycosylphosphatidylinositol (GPI)-specific phospholipase that primarily localizes to the Golgi apparatus. This ubiquitously expressed gene is predicted to encode a seven-transmembrane protein that removes unsaturated fatty acids from the sn-2 position of GPI. The remodeling of the constituent fatty acids on GPI is thought to be important for the proper association between GPI-anchored proteins and lipid rafts. The tethering of proteins to plasma membranes via posttranslational GPI-anchoring is thought to play a role in protein sorting and trafficking. Mutations in this gene cause an autosomal recessive form of neurologic hyperphosphatasia with cognitive disability (HPMRS4). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22245 PGAP3 Knockout cell line (HeLa) Human PGAP3 1:3~1:6 Negative Online Inquiry
KO22246 PGAP3 Knockout cell line (HCT 116) Human PGAP3 1:2~1:4 Negative Online Inquiry
KO22247 PGAP3 Knockout cell line (HEK293) Human PGAP3 1:3~1:6 Negative Online Inquiry
KO22248 PGAP3 Knockout cell line (A549) Human PGAP3 1:3~1:4 Negative Online Inquiry

Background

PGAP3 Gene Knockout Cell Lines are specifically designed cellular tools in which the PGAP3 gene has been functionally disrupted to study its biological role and implications in various physiological and pathological contexts. The PGAP3 gene encodes a protein that is involved in the post-translational modification of proteins, particularly in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. The knockout of this gene enables researchers to investigate the downstream effects on GPI-anchored proteins and their contribution to cellular functions such as adhesion, signaling, and immune responses.

The functionality of PGAP3 Gene Knockout Cell Lines lies in their ability to provide a robust model to elucidate the pathways affected by the loss of PGAP3 expression. By analyzing these cell lines, scientists can delve into essential research areas, such as cell signaling, immune regulation, and cancer biology, making them invaluable in preclinical investigations and therapeutic developments.

In clinical settings, these cell lines hold potential for advancing our understanding of disorders linked to GPI-anchor deficiencies, such as certain types of immunodeficiencies and neurological diseases. Their specific design allows for comparative studies with wild-type cells, offering insights into the mechanistic roles of PGAP3 in health and disease.

One of the standout advantages of our PGAP3 Gene Knockout Cell Lines over alternatives is the precision and efficiency of the gene editing techniques employed to create these models. With guaranteed consistency and reproducibility across experiments, these cell lines reduce variability, enhancing the reliability of research outcomes. Moreover, they come with a thorough characterization report, ensuring that researchers have a comprehensive understanding of their phenotypic and genotypic status.

For researchers and clinicians alike, the value of PGAP3 Gene Knockout Cell Lines extends beyond basic research; they represent a critical resource for discovering novel therapeutic targets and strategies. Our commitment at [Company Name] to providing high-quality biological products is underscored by extensive experience in gene editing techniques and cellular model development, ensuring that our users benefit from the utmost reliability and innovation in their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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