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PDLIM7 Knockout Cell Lines

Gene: PDLIM7

Official Full Name: PDZ and LIM domain 7provided by HGNC

Gene Summary: The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33374 PDLIM7 Knockout cell line (HeLa) Human PDLIM7 1:3~1:6 Negative Online Inquiry
KO33375 PDLIM7 Knockout cell line (HCT 116) Human PDLIM7 1:2~1:4 Negative Online Inquiry
KO33376 PDLIM7 Knockout cell line (HEK293) Human PDLIM7 1:3~1:6 Negative Online Inquiry
KO33377 PDLIM7 Knockout cell line (A549) Human PDLIM7 1:3~1:4 Negative Online Inquiry

Background

PDLIM7 Gene Knockout Cell Lines are specialized cellular models engineered to selectively disable the PDLIM7 gene, which encodes a member of the PDZ-LIM domain protein family. This innovative product allows researchers to investigate the functional role of PDLIM7 in cellular processes such as signal transduction, cytoskeletal organization, and gene expression regulation. Utilizing CRISPR/Cas9 technology, these knockout cell lines provide a precise and efficient means to disrupt the PDLIM7 gene, offering unparalleled control over experimental variables.

The primary mechanism by which PDLIM7 knockout cell lines operate hinges on the targeted deletion of specific genomic sequences within the PDLIM7 locus. By creating a complete loss of function in PDLIM7, researchers can study the resultant phenotypic changes, enabling insights into how PDLIM7 contributes to cellular behavior and pathophysiology. This is especially crucial in research contexts focused on development, cancer biology, and neurodegenerative diseases, where PDLIM7 is known to play significant roles.

The scientific importance of these cell lines is underscored by their versatile applications in both basic and applied research settings. They serve as vital tools for functional genomics, drug discovery, and mechanism-of-action studies, providing a means to elucidate the biological underpinnings of disease and therapeutic responses. Compared to traditional cell models, such as those with non-specific gene silencing methods, these knockout lines provide a higher level of specificity, ensuring reliable and reproducible results.

Furthermore, the unique selling points of PDLIM7 Gene Knockout Cell Lines include their ready-to-use format, customizable applications for different research areas, and the capacity to generate important data on gene function. The ability to systematically interrogate the influence of the PDLIM7 gene contributes significantly to advancing our understanding of complex biological systems.

For researchers and clinicians seeking to innovate and deepen their understanding of cellular mechanisms, PDLIM7 Gene Knockout Cell Lines offer a cutting-edge solution. With a robust portfolio in the development of unique biological products, our company is dedicated to enabling breakthrough research and clinical advancements, ensuring that scientists have access to the most effective tools for their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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