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PCOLCE2 Knockout Cell Lines

Gene: PCOLCE2

Official Full Name: procollagen C-endopeptidase enhancer 2provided by HGNC

Gene Summary: Enables collagen binding activity; heparin binding activity; and peptidase activator activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05234 PCOLCE2 Knockout cell line (HeLa) Human PCOLCE2 1:3~1:6 Negative Online Inquiry
KO05235 PCOLCE2 Knockout cell line (HCT 116) Human PCOLCE2 1:2~1:4 Negative Online Inquiry
KO05236 PCOLCE2 Knockout cell line (HEK293) Human PCOLCE2 1:3~1:6 Negative Online Inquiry
KO05237 PCOLCE2 Knockout cell line (A549) Human PCOLCE2 1:3~1:4 Negative Online Inquiry

Background

PCOLCE2 Gene Knockout Cell Lines are specialized in vitro models that have been engineered to lack the expression of the PCOLCE2 gene, which encodes the procollagen C-endopeptidase enhancer 2 protein involved in collagen processing and extracellular matrix (ECM) remodeling. By specifically targeting and inactivating this gene, these cell lines facilitate the study of ECM-related processes and their implications in various biological pathways and diseases.

The central function of the PCOLCE2 gene knockout cell lines lies in their ability to elucidate the role of PCOLCE2 in cellular behavior, including proliferation, differentiation, and apoptosis. The absence of PCOLCE2 proteins enables researchers to investigate downstream effects on collagen metabolism and the overall integrity of the ECM. This is particularly crucial for understanding conditions such as fibrosis, cancer metastasis, and wound healing disorders, where altered ECM dynamics play a vital role.

From a scientific standpoint, these cell lines hold significant value in both fundamental research and translational applications, thereby contributing to a deeper understanding of numerous pathologies. Their use in drug discovery and development studies offers a more precise framework for evaluating potential therapeutics aimed at modulating ECM processes and improving tissue regeneration strategies.

What sets our PCOLCE2 Gene Knockout Cell Lines apart from existing alternatives is their high specificity and the robust genetic modification techniques used to achieve the knockout, ensuring reproducibility and consistency across experiments. Additionally, our extensive characterization of these lines confirms their stability and functionality for use in diverse experimental setups.

Researchers and clinicians using our product benefit from the assurance of quality and reliability, which are critical in yielding accurate and publishable results. The PCOLCE2 Gene Knockout Cell Lines can serve as a vital tool for anyone looking to advance their understanding of ECM-related diseases or develop novel therapeutic approaches.

With a strong background in biotechnology and a commitment to delivering only the highest-quality biological products, our company is well-equipped to support researchers and clinicians in their scientific endeavors, ensuring they have the best tools available to drive innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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