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PCLO Knockout Cell Lines

Gene: PCLO

Official Full Name: piccolo presynaptic cytomatrix proteinprovided by HGNC

Gene Summary: The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27589 PCLO Knockout cell line (HeLa) Human PCLO 1:3~1:6 Negative Online Inquiry
KO27590 PCLO Knockout cell line (HCT 116) Human PCLO 1:2~1:4 Negative Online Inquiry
KO27591 PCLO Knockout cell line (HEK293) Human PCLO 1:3~1:6 Negative Online Inquiry

Background

PCLO Gene Knockout Cell Lines are genetically engineered models that have been specifically created to ablate the PCLO gene, which encodes the protein synaptophysin-like 1. These cell lines serve as essential tools for investigating the role of PCLO in cellular processes, particularly in synaptic transmission and neuronal function. By employing CRISPR-Cas9 technology, these knockout cell lines ensure the complete disruption of the PCLO gene, providing a reliable system for studying gene function in various biological contexts.

The primary mechanism of action for the PCLO Gene Knockout Cell Lines involves the targeted editing of the genome, leading to the loss of function of the associated protein. This alteration enables researchers to explore the biological impact of PCLO deficiency on neurotransmitter release, synaptic plasticity, and overall neuronal health. In clinical research, these models can be instrumental in elucidating mechanisms underlying neuropsychiatric disorders, thereby paving the way for potential therapeutic targets.

One of the standout advantages of the PCLO Gene Knockout Cell Lines is their specificity and precision in gene editing. Unlike traditional models, which may exhibit off-target effects or incomplete knockout, these lines provide consistent results with minimal variability, increasing the reliability of experimental data. Furthermore, they offer a simplified approach to studying complex biological phenomena, allowing for efficient hypothesis testing and experimental validation.

Researchers and clinicians will find immense value in the PCLO Gene Knockout Cell Lines as they contribute to a deeper understanding of neurological conditions and aid in the identification of novel drug targets. By integrating advanced cellular assays with these knockout models, users can accelerate their research efforts in neurobiology, ultimately advancing the field toward improved clinical outcomes.

Our company is dedicated to delivering high-quality biological products that empower scientific research. With a focus on innovation and reliability, we ensure that our product offerings, such as the PCLO Gene Knockout Cell Lines, meet the rigorous demands of researchers and clinicians, facilitating breakthroughs in understanding human biology.

Please note that all services are for research use only. Not intended for any clinical use.

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