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PCDHA@ Knockout Cell Lines

Gene: PCDHA@

Official Full Name: protocadherin alpha cluster, complex locusprovided by HGNC

Gene Summary: The protocadherin alpha gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have a genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 genes and 1 pseudogene, which are members of the cadherin superfamily and related to the mouse CNR genes. The sequence of the 13 upstream genes and the pseudogene are highly similar to one another, while a subfamily (C) contains two more distantly related coding sequences. The alpha cluster genes are organized in a tandem array of 15 large, variable region exons followed by a constant region, which contains 3 exons shared by all genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the alpha cluster genes. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20969 PCDHA@ Knockout cell line (HeLa) Human PCDHA@ 1:3~1:6 Negative Online Inquiry
KO20970 PCDHA@ Knockout cell line (HCT 116) Human PCDHA@ 1:2~1:4 Negative Online Inquiry
KO20971 PCDHA@ Knockout cell line (HEK293) Human PCDHA@ 1:3~1:6 Negative Online Inquiry
KO20972 PCDHA@ Knockout cell line (A549) Human PCDHA@ 1:3~1:4 Negative Online Inquiry

Background

PCDHA@ Gene Knockout Cell Lines represent a cutting-edge tool for researchers focusing on the functional genomics of the protocadherin-alpha (PCDHA) gene cluster, which plays a critical role in neuronal development and synaptic plasticity. These knockout cell lines have been meticulously engineered to provide a robust platform for studying the specific contributions of PCDHA genes in various biological processes, including cell adhesion, signaling pathways, and neuronal network formation.

The key mechanism by which PCDHA@ Gene Knockout Cell Lines operate involves the targeted deletion of specific PCDHA genes, allowing researchers to delineate the individual effects of these genes on cellular behavior and neural circuitry. By utilizing techniques such as CRISPR-Cas9 gene editing, these cell lines ensure precise and reproducible results, enabling comprehensive analyses of gene function in both cellular and animal models.

The scientific importance of PCDHA@ Gene Knockout Cell Lines cannot be overstated, particularly in the context of neurological research. Alterations in PCDHA gene expression have been implicated in a range of neurodevelopmental disorders, making these cell lines invaluable for elucidating disease mechanisms, identifying potential therapeutic targets, and screening compounds that may modulate PCDHA activity.

One of the primary advantages of our PCDHA@ Gene Knockout Cell Lines lies in their specificity and efficiency, distinguishing them from more generalized knockout systems. Unlike traditional methods, which may yield off-target effects or incomplete knockouts, our carefully optimized lines offer a high degree of fidelity in gene disruption. This leads to more accurate models of human diseases and enhances the reliability of experimental results across studies.

For researchers and clinicians, the value of PCDHA@ Gene Knockout Cell Lines extends beyond mere functionality; they provide a unique opportunity to investigate complex biological interactions and advance understanding in neurobiology. The ability to manipulate PCDHA gene expression in a controlled manner equips users with a powerful means to explore innovative treatments and interventions.

Our company prides itself on its expertise in developing high-quality biological products tailored for cutting-edge research and clinical applications. With a commitment to supporting the scientific community, we empower researchers with reliable tools that facilitate transformative discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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