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PBK Knockout Cell Lines

Gene: PBK

Official Full Name: PDZ binding kinaseprovided by HGNC

Gene Summary: This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00366 PBK Knockout cell line(U-2OS) Human PBK 1:3~1:5 Negative Online Inquiry
KO20103 PBK Knockout cell line (HeLa) Human PBK 1:3~1:6 Negative Online Inquiry
KO20104 PBK Knockout cell line (HCT 116) Human PBK 1:2~1:4 Negative Online Inquiry
KO20105 PBK Knockout cell line (HEK293) Human PBK 1:3~1:6 Negative Online Inquiry
KO20106 PBK Knockout cell line (A549) Human PBK 1:3~1:4 Negative Online Inquiry

Background

PBK Gene Knockout Cell Lines are specialized cellular models specifically engineered to knock out the PBK gene, which encodes a serine/threonine kinase involved in various cellular processes, including cell proliferation and migration. This product offers researchers a valuable tool for dissecting the biological roles of PBK in normal physiology and pathology, particularly in cancer biology and developmental studies.

These cell lines utilize advanced CRISPR-Cas9 gene-editing technology to induce targeted gene disruption, ensuring a precise and efficient knockout of the PBK gene. The absence of PBK function in these cell lines allows for the exploration of downstream signaling pathways and cellular responses that are often modified in disease states. This mechanistic understanding can pave the way for the identification of novel therapeutic targets or biomarkers.

Scientifically, these cell lines are crucial for various applications, including drug discovery, functional genomics, and translational research, where understanding the role of specific genes in disease can facilitate the development of more effective treatments. Moreover, they provide a robust platform for studying gene function in a controlled environment, enabling reproducibility and reliability in experimental outcomes.

Compared to other gene knockout models, PBK Gene Knockout Cell Lines are particularly advantageous due to their rapid generation, high efficiency, and the ability to maintain stable genetic modifications over multiple passages, which ensures consistency in experimental assays. Additionally, their compatibility with high-throughput screening systems makes them indispensable in large-scale research projects.

For researchers and clinicians focused on oncology and regenerative medicine, PBK Gene Knockout Cell Lines offer unique insights into the molecular mechanisms underpinning disease, making them a valuable addition to any laboratory resource. At [Your Company], we are committed to providing cutting-edge biological products backed by extensive expertise in gene editing technologies, ensuring that our customers have access to the best tools for their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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