Gene: PATZ1
Official Full Name: POZ/BTB and AT hook containing zinc finger 1provided by HGNC
Gene Summary: The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29084 | PATZ1 Knockout cell line (HeLa) | Human | PATZ1 | 1:3~1:6 | Negative | Online Inquiry |
KO29085 | PATZ1 Knockout cell line (HCT 116) | Human | PATZ1 | 1:2~1:4 | Negative | Online Inquiry |
KO29086 | PATZ1 Knockout cell line (HEK293) | Human | PATZ1 | 1:3~1:6 | Negative | Online Inquiry |
KO29087 | PATZ1 Knockout cell line (A549) | Human | PATZ1 | 1:3~1:4 | Negative | Online Inquiry |
PATZ1 Gene Knockout Cell Lines are genetically modified cells that have been specifically engineered to lack the PATZ1 gene, which encodes a protein implicated in various cellular processes including gene regulation, apoptosis, and DNA repair. By creating a complete knockout of this gene, researchers can investigate its functional roles and understand its contribution to cellular homeostasis or disease mechanisms more comprehensively.
The key functions of PATZ1 Gene Knockout Cell Lines revolve around the ability to unravel the implications of PATZ1 in cellular pathways. This knockout model enables scientists to study alterations in gene expression profiles, cellular growth patterns, and apoptosis rates when PATZ1 is absent. The degradation of these pathways can provide critical insights into conditions such as cancer, where dysregulation of gene expression is common. Additionally, using this cell line allows for drug screening efforts aimed at targeting aberrant processes related to PATZ1 function.
In research and clinical settings, PATZ1 Gene Knockout Cell Lines hold significant scientific importance. They can be instrumental in elucidating the molecular underpinning of diseases, particularly those where PATZ1 has been implicated, such as certain cancers. Moreover, they serve as a powerful tool for screening potential therapeutic agents and understanding how the absence of PATZ1 affects drug responses, thus offering insights into improves treatment strategies.
One of the main advantages of utilizing PATZ1 Gene Knockout Cell Lines is the specificity and robustness of this model. Compared to alternative systems, such as RNA interference or transient gene silencing approaches, these knockout lines present a more stable and permanent solution that allows for prolonged studies without the risk of reconstituting the PATZ1 gene product. This permanence enhances reproducibility and reliability in experimental results, making these cell lines an invaluable asset for researchers.
The value of PATZ1 Gene Knockout Cell Lines cannot be overstated for researchers focused on gene function and its implications on human health. With the ability to deeply investigate gene-related pathways, clinicians can also leverage this product for personalized medicine approaches, tailoring treatments based on cellular responses mediated by PATZ1.
At [Your Company Name], our commitment to advancing genetic research is evident in our high-quality offerings, including the PATZ1 Gene Knockout Cell Lines. We strive to provide innovative biological products that empower researchers and clinicians alike to make significant breakthroughs in understanding human health.
Please note that all services are for research use only. Not intended for any clinical use.
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