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PARVB Knockout Cell Lines

Gene: PARVB

Official Full Name: parvin betaprovided by HGNC

Gene Summary: This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27045 PARVB Knockout cell line (HeLa) Human PARVB 1:3~1:6 Negative Online Inquiry
KO27046 PARVB Knockout cell line (HCT 116) Human PARVB 1:2~1:4 Negative Online Inquiry
KO27047 PARVB Knockout cell line (HEK293) Human PARVB 1:3~1:6 Negative Online Inquiry
KO27048 PARVB Knockout cell line (A549) Human PARVB 1:3~1:4 Negative Online Inquiry

Background

PARVB Gene Knockout Cell Lines represent a cutting-edge tool designed for the study of the ParvB gene, which plays a critical role in various cellular processes, including cell proliferation, apoptosis, and response to stress. These cell lines are genetically modified to lack functional PARVB, enabling researchers to elucidate its biological functions and contributions to disease mechanisms.

The key function of PARVB Gene Knockout Cell Lines lies in their ability to provide a model for investigating the downstream effects of PARVB loss. This is achieved through advanced gene-editing techniques, such as CRISPR/Cas9, which precisely disrupt the PARVB gene, creating a knockout phenotype. Researchers can utilize these cell lines to assess changes in cellular signaling pathways, morphology, and behavior when PARVB is absent, thereby contributing to a better understanding of its role in various physiological and pathological contexts.

The scientific importance of these cell lines is underscored by their applications in both research and clinical settings. In cancer research, for instance, understanding the role of PARVB in tumorigenesis can lead to novel therapeutic strategies targeting PARVB-related pathways. Additionally, these tools can help investigate the gene's involvement in diseases such as cardiovascular disorders and neurodegenerative conditions, advancing the field of precision medicine.

Compared to alternative models, PARVB Gene Knockout Cell Lines offer distinct advantages, including their specificity, reproducibility, and the ability to observe physiological responses without compensatory mechanisms that are often present in traditional knockout models. Furthermore, the versatility of these cell lines allows for their use in various cell types, enabling comprehensive studies across multiple research domains.

For researchers and clinicians, investing in PARVB Gene Knockout Cell Lines means gaining access to an innovative platform that facilitates deeper insights into critical biological questions, driving forward the frontier of biomedical research. Our company prides itself on its commitment to excellence in genetic modification technologies, providing high-quality research tools validated by extensive testing and expertise in the field. Whether in academia or industry, with our PARVB Gene Knockout Cell Lines, you equip your research with the precision necessary to advance scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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