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PANK4 Knockout Cell Lines

Gene: PANK4

Official Full Name: pantothenate kinase 4 (inactive)provided by HGNC

Gene Summary: This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20160 PANK4 Knockout cell line (HeLa) Human PANK4 1:3~1:6 Negative Online Inquiry
KO20161 PANK4 Knockout cell line (HCT 116) Human PANK4 1:2~1:4 Negative Online Inquiry
KO20162 PANK4 Knockout cell line (HEK293) Human PANK4 1:3~1:6 Negative Online Inquiry
KO20163 PANK4 Knockout cell line (A549) Human PANK4 1:3~1:4 Negative Online Inquiry

Background

PANK4 Gene Knockout Cell Lines are engineered cellular models that precisely lack the function of the pantothenate kinase 4 (PANK4) gene, which is integral in the synthesis of coenzyme A and energy metabolism. Created using advanced CRISPR/Cas9 gene editing technology, these cell lines enable researchers to study the role of PANK4 in cellular processes such as lipid metabolism, oxidative stress response, and overall cellular health.

The primary function of PANK4 Gene Knockout Cell Lines lies in their utility for elucidating the gene’s contributions to metabolic pathways and pathological conditions. By completely knocking out the PANK4 gene, these models facilitate the investigation of cellular adaptations, compensatory mechanisms, and the functional significance of coenzyme A-dependent pathways, particularly in conditions like metabolic syndrome, cancer, and neurodegenerative diseases.

The scientific importance of PANK4 knockouts extends to providing robust platforms for drug discovery and therapeutic development. These cell lines can be utilized to screen compounds that target metabolic dysregulation, making them valuable assets in both academic research and clinical settings seeking to explore metabolic diseases. Moreover, the ability to analyze effects in a controlled environment enhances the reproducibility and accuracy of experimental results.

What sets PANK4 Gene Knockout Cell Lines apart from alternative models is their specificity and the precision of the knockout, which eliminates off-target effects commonly associated with less sophisticated editing techniques. Additionally, these cell lines are readily available and validated by rigorous testing to ensure consistent performance in various applications.

For researchers and clinicians aiming to expand their understanding of metabolic pathways or develop new therapeutic strategies, the PANK4 Gene Knockout Cell Lines represent a critical tool that bridges fundamental biology and translational medicine. Our company is dedicated to providing high-quality biological products, backed by extensive expertise in genetic engineering and a commitment to empowering cutting-edge research in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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