Gene: PANK2
Official Full Name: pantothenate kinase 2provided by HGNC
Gene Summary: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26280 | PANK2 Knockout cell line (HeLa) | Human | PANK2 | 1:3~1:6 | Negative | Online Inquiry |
KO26281 | PANK2 Knockout cell line (HCT 116) | Human | PANK2 | 1:2~1:4 | Negative | Online Inquiry |
KO26282 | PANK2 Knockout cell line (HEK293) | Human | PANK2 | 1:3~1:6 | Negative | Online Inquiry |
KO26283 | PANK2 Knockout cell line (A549) | Human | PANK2 | 1:3~1:4 | Negative | Online Inquiry |
PANK2 Gene Knockout Cell Lines are specialized cellular models designed to facilitate research on the PANK2 gene, a critical player in pantothenic acid metabolism within the human body. The PANK2 gene encodes the enzyme pantothenate kinase 2, which is involved in the regulation of coenzyme A biosynthesis. By creating knockout models where the PANK2 gene is inactivated, researchers can investigate the downstream effects of disrupted metabolic pathways that may contribute to various pathologies, including neurodegenerative disorders, such as Pantothenate Kinase-Associated Neurodegeneration (PKAN).
These cell lines allow for precise manipulation and observation of cellular responses, enabling scientists to elucidate the role of PANK2 in cell signaling, energy metabolism, and disease progression. The mechanisms by which PANK2 influences these pathways can be studied more deeply using our knockout models, paving the way for potential therapeutic interventions.
The scientific importance of PANK2 Gene Knockout Cell Lines extends to both basic research and translational applications. They serve as invaluable tools for pharmaceutical development and gene therapy research, facilitating the identification of drug candidates aimed at ameliorating conditions associated with PANK2 mutations.
Compared to traditional models, our PANK2 knockout cell lines offer enhanced genetic specificity and greater reproducibility, eliminating off-target effects that could skew results. Researchers will appreciate the time-saving aspect of utilizing these ready-to-use cell lines, which can significantly speed up the experimental process.
For laboratories dedicated to advancing our understanding of metabolic diseases and neurobiology, investing in PANK2 Gene Knockout Cell Lines provides an opportunity to contribute to groundbreaking discoveries. Our company, an industry leader in the development of innovative genetic tools, is committed to equipping researchers with high-quality products that drive scientific progress and improve clinical outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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