Gene: PAGR1
Official Full Name: PAXIP1 associated glutamate rich protein 1provided by HGNC
Gene Summary: Enables nuclear estrogen receptor binding activity. Involved in positive regulation of cell cycle G1/S phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MLL3/4 complex. Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20234 | PAGR1 Knockout cell line (HeLa) | Human | PAGR1 | 1:3~1:6 | Negative | Online Inquiry |
KO20235 | PAGR1 Knockout cell line (HCT 116) | Human | PAGR1 | 1:2~1:4 | Negative | Online Inquiry |
KO20236 | PAGR1 Knockout cell line (HEK293) | Human | PAGR1 | 1:3~1:6 | Negative | Online Inquiry |
KO20237 | PAGR1 Knockout cell line (A549) | Human | PAGR1 | 1:3~1:4 | Negative | Online Inquiry |
PAGR1 Gene Knockout Cell Lines are advanced cellular models designed to facilitate the study of the PAGR1 gene, which plays a significant role in various cellular processes, including apoptosis, transcription regulation, and immune responses. Utilizing CRISPR-Cas9 technology, these knockouts specifically target and disrupt the PAGR1 gene, allowing researchers to analyze the resulting phenotypic variations and explore the gene’s functional implications in different biological contexts.
The key mechanism behind PAGR1 Gene Knockout Cell Lines lies in their ability to provide a controlled environment to investigate the absence of the PAGR1 protein. By observing these cells, researchers can uncover the gene's contributions to cellular signaling pathways and its involvement in disease states, particularly in cancer and autoimmune disorders. In clinical research, this tool is invaluable for validating potential therapeutic targets and assessing the efficacy of novel drugs.
One of the significant advantages of PAGR1 Gene Knockout Cell Lines over traditional methods is the precision in gene disruption afforded by CRISPR technology, which not only enhances the reproducibility of experimental findings but also minimizes off-target effects. Furthermore, these cell lines are readily available and adaptable for high-throughput screening, making them accessible for large-scale studies.
The value of PAGR1 Gene Knockout Cell Lines to researchers and clinicians lies in their ability to deepen the understanding of gene function and interactions, ultimately driving innovation in therapeutic approaches. Their application can lead to significant breakthroughs in personalized medicine, where genetic insights guide tailored treatments.
Our company specializes in the development of high-quality biological products, including customized gene knockout services and genetically engineered cell lines, backed by years of collaborative research with leading institutions. We are committed to advancing biomedical research by providing sophisticated tools that empower scientists to push the boundaries of discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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