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PAFAH1B2 Knockout Cell Lines

Gene: PAFAH1B2

Official Full Name: platelet activating factor acetylhydrolase 1b catalytic subunit 2provided by HGNC

Gene Summary: Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36230 PAFAH1B2 Knockout cell line (HeLa) Human PAFAH1B2 1:3~1:6 Negative Online Inquiry
KO36231 PAFAH1B2 Knockout cell line (HCT 116) Human PAFAH1B2 1:2~1:4 Negative Online Inquiry
KO36232 PAFAH1B2 Knockout cell line (HEK293) Human PAFAH1B2 1:3~1:6 Negative Online Inquiry
KO36233 PAFAH1B2 Knockout cell line (A549) Human PAFAH1B2 1:3~1:4 Negative Online Inquiry

Background

PAFAH1B2 Gene Knockout Cell Lines are genetically modified cellular systems designed to facilitate the study of the PAFAH1B2 gene, which encodes for an enzyme involved in phospholipid metabolism and apoptotic signaling pathways. These knockout cell lines are created using advanced CRISPR-Cas9 technology to precisely delete the PAFAH1B2 gene, thereby enabling researchers to investigate the functional consequences of its absence on cellular behavior, signaling processes, and overall physiological responses.

The key function of PAFAH1B2 involves the breakdown of lysolipids, which play critical roles in cell signaling and membrane dynamics. By employing these knockout cell lines, scientists can elucidate the mechanistic pathways mediated by PAFAH1B2 and assess its impact on processes such as apoptosis, inflammation, and lipid metabolism. This functionality is particularly valuable for investigations related to neurodegenerative diseases, metabolic disorders, and various forms of cancer, as PAFAH1B2 has been implicated in the pathology of these conditions.

The scientific importance of PAFAH1B2 Gene Knockout Cell Lines extends to both research and clinical settings. In research, these cell lines provide a powerful tool for understanding gene function and interactions within complex biological systems. Clinically, they can serve as a platform for drug discovery, allowing for the screening of new therapeutics targeted at conditions modulated by PAFAH1B2 activity.

One distinct advantage of our PAFAH1B2 Gene Knockout Cell Lines is the high specificity and efficiency achieved through our proprietary gene-editing protocols, which ensure minimal off-target effects. This precision translates to more reliable and reproducible results compared to alternative methods such as RNA interference or traditional knockout techniques. Moreover, our cell lines are extensively validated to ensure their functional integrity and suitability for downstream applications, which saves valuable time in experimental design.

For researchers and clinicians, valuing this product lies not only in its capacity to drive significant scientific insights but also in its potential to advance therapeutic developments. The ability to manipulate and observe the absence of a gene of interest greatly enhances our understanding of disease mechanisms and opens avenues for innovative intervention strategies.

Our company prides itself on its commitment to quality and innovation in the field of genetic engineering. With a robust portfolio of biological products and a team of experts dedicated to providing the highest standards of research tools, we stand ready to support your research endeavors with our PAFAH1B2 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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