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PACRG Knockout Cell Lines

Gene: PACRG

Official Full Name: parkin coregulatedprovided by HGNC

Gene Summary: This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26408 PACRG Knockout cell line (HEK293) Human PACRG 1:3~1:6 Negative Online Inquiry

Background

PACRG Gene Knockout Cell Lines are genetically engineered cell lines that have been systematically modified to disrupt the expression of the PACRG gene. This gene, which encodes for a protein involved in cellular processes such as inflammation and cellular growth, is essential for understanding a range of biological functions and diseases. These knockout cell lines enable researchers to elucidate the functional role of the PACRG protein by providing a controlled environment for experimental manipulation and observation.

The key function of PACRG Gene Knockout Cell Lines lies in their ability to serve as a valuable tool for investigating the gene's involvement in various physiological and pathological processes. By employing CRISPR/Cas9 gene editing technology, these cell lines exhibit a complete absence of PACRG protein expression, allowing researchers to explore resultant cellular behaviors, signaling pathways, and potential compensatory mechanisms that may arise in its absence. This mechanistic insight is critical for projects aimed at identifying therapeutic targets for diseases related to dysregulated PACRG activity, including certain cancers and autoimmune disorders.

In the realm of scientific research and clinical applications, these cell lines present robust advantages. The precise and reproducible nature of the gene knockout ensures consistent results across experiments, thereby enhancing the validity of findings. Compared to traditional methods of gene manipulation, such as siRNA knockdown, PACRG Gene Knockout Cell Lines offer a permanent solution that can significantly reduce variability and increase the reliability of experimental outcomes.

For researchers and clinicians focused on gene function analysis, drug discovery, or translational research, these cell lines provide a unique opportunity to dissect molecular pathways with high specificity and applicability. They enable accelerated discovery processes and can support preclinical studies by offering insights that are directly relevant to human health and disease implications.

Our company has a longstanding commitment to advancing research with cutting-edge genetic tools and resources. With our expertise in gene editing and cellular technologies, we are well-positioned to support your research endeavors with high-quality PACRG Gene Knockout Cell Lines that meet the highest standards of scientific rigor.

Please note that all services are for research use only. Not intended for any clinical use.

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