Home / P3H4 Knockout Cell Lines

P3H4 Knockout Cell Lines

Gene: P3H4

Official Full Name: prolyl 3-hydroxylase family member 4 (inactive)provided by HGNC

Gene Summary: This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31662 P3H4 Knockout cell line (HeLa) Human P3H4 1:3~1:6 Negative Online Inquiry
KO31663 P3H4 Knockout cell line (HCT 116) Human P3H4 1:2~1:4 Negative Online Inquiry
KO31664 P3H4 Knockout cell line (HEK293) Human P3H4 1:3~1:6 Negative Online Inquiry
KO31665 P3H4 Knockout cell line (A549) Human P3H4 1:3~1:4 Negative Online Inquiry

Background

P3H4 Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the P3H4 gene's function in a controlled environment. The knockout technique involves the targeted disruption of this gene using precise genome editing technologies, such as CRISPR-Cas9, leading to the ablation of its expression. This cellular model is crucial for researchers aiming to elucidate the biological pathways and consequences associated with the loss of P3H4 function, particularly in relation to its role in collagen synthesis and tissue remodeling.

The key functions of P3H4 are embedded in its involvement in the post-translational modification of collagen, impacting extracellular matrix stability and cellular response during wound healing and fibrosis. By using P3H4 gene knockout cell lines, scientists can investigate the molecular mechanisms driving connective tissue disorders, assess potential therapeutic targets, and evaluate the implications of P3H4 deficiency in various disease contexts.

The scientific importance of these cell lines extends to both research and clinical applications. They are indispensable in drug discovery processes, toxicity assessments, and understanding fundamental biological questions. As researchers explore potential treatments for fibrotic diseases and other collagen-related pathologies, P3H4 knockout models serve as vital tools for screening compounds that could restore normal cellular function.

A significant advantage of P3H4 gene knockout cell lines compared to traditional models is their specificity and precision, which allow for more granular insights into gene functions and disease mechanisms. Unlike non-specific inhibitors or general knockdown strategies, these knockout lines provide a complete loss-of-function scenario, thereby enhancing the relevance of experimental outcomes.

For researchers and clinicians, the value of P3H4 gene knockout cell lines lies in their versatility and reliability as a platform for innovative research. Given the complexity of genetic interactions, these models not only streamline the investigation of specific gene functions but also pave the way for breakthroughs in therapeutic strategies.

Driven by our commitment to advancing biomedical research, our company specializes in producing high-quality gene knockout cell lines, ensuring that researchers have access to the cutting-edge tools necessary for their studies.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.