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OXR1 Knockout Cell Lines

Gene: OXR1

Official Full Name: oxidation resistance 1provided by HGNC

Gene Summary: Predicted to enable oxidoreductase activity. Predicted to be involved in response to oxidative stress. Predicted to act upstream of or within several processes, including adult walking behavior; negative regulation of cellular response to oxidative stress; and negative regulation of peptidyl-cysteine S-nitrosylation. Located in mitochondrion. Implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15412 OXR1 Knockout cell line (HeLa) Human OXR1 1:3~1:6 Negative Online Inquiry
KO15413 OXR1 Knockout cell line (HCT 116) Human OXR1 1:2~1:4 Negative Online Inquiry
KO15414 OXR1 Knockout cell line (HEK293) Human OXR1 1:3~1:6 Negative Online Inquiry
KO15415 OXR1 Knockout cell line (A549) Human OXR1 1:3~1:4 Negative Online Inquiry

Background

OXR1 Gene Knockout Cell Lines are specially engineered cellular models where the OXR1 gene has been inactivated to enable researchers to study the functional implications of OXR1 depletion. The OXR1 gene, known for its role in maintaining oxidative stress response and cellular integrity, is crucial for understanding various biological processes, particularly those involving cellular stress responses, DNA repair mechanisms, and mitochondrial function. By creating knockout cell lines, scientists can investigate the resultant phenotypic and molecular changes that occur in the absence of OXR1, providing insights into its contributions to cellular homeostasis and disease pathology.

The key mechanism of action of these knockout cell lines lies in their ability to mimic stress conditions relevant to human diseases by eliminating the OXR1 protective pathways. Researchers can explore how the lack of OXR1 influences reactive oxygen species (ROS) management, thereby elucidating its impact on oxidative stress-related disorders such as neurodegenerative diseases, cancer, and aging. In a clinical context, this model can assist in drug discovery processes, offering a platform to test therapeutic interventions targeting oxidative stress.

The scientific importance of OXR1 Gene Knockout Cell Lines is pronounced in both research and clinical applications. They serve as invaluable tools for investigating the role of oxidative stress in various pathologies, significantly enhancing our understanding of disease mechanisms and potential therapeutic strategies. Unlike traditional wild-type cell lines, these knockout lines provide a clearer representation of disease states, allowing for more precise experimental outcomes.

One of the distinct advantages of our OXR1 Gene Knockout Cell Lines is their specificity and reliability. Each line is created using advanced CRISPR/Cas9 technology, ensuring precise gene editing with minimal off-target effects. Furthermore, these cell lines are validated for consistency and reproducibility across experiments, which is essential for producing reliable data.

For researchers and clinicians focused on advancements in molecular biology, genetics, or therapeutic development, OXR1 Gene Knockout Cell Lines provide a credible and practical resource. Their ability to facilitate targeted investigations into oxidative stress mechanisms underscores their value in enhancing our understanding of health and disease.

At [Your Company Name], we are committed to providing cutting-edge biological products that empower scientific innovation. With our expertise in cell line development and gene editing technologies, we continuously strive to support researchers in unlocking new avenues of discovery in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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