Gene: OTUD3
Official Full Name: OTU deubiquitinase 3provided by HGNC
Gene Summary: Enables cysteine-type deubiquitinase activity. Involved in cellular response to nutrient levels and protein deubiquitination. Acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; protein deubiquitination; and protein stabilization. Located in cytoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29599 | OTUD3 Knockout cell line (HeLa) | Human | OTUD3 | 1:3~1:6 | Negative | Online Inquiry |
KO29600 | OTUD3 Knockout cell line (HCT 116) | Human | OTUD3 | 1:2~1:4 | Negative | Online Inquiry |
KO29601 | OTUD3 Knockout cell line (HEK293) | Human | OTUD3 | 1:3~1:6 | Negative | Online Inquiry |
KO29602 | OTUD3 Knockout cell line (A549) | Human | OTUD3 | 1:3~1:4 | Negative | Online Inquiry |
OTUD3 Gene Knockout Cell Lines are genetically engineered cell lines in which the OTUD3 gene has been silenced or disrupted utilizing advanced CRISPR-Cas9 gene editing technology. The OTUD3 gene encodes a deubiquitinating enzyme that plays a crucial role in regulating protein stability and modulation of various cellular processes, including inflammation and stress response pathways. By knocking out this gene, researchers can examine the downstream effects on cellular signaling, apoptosis, and overall cell viability, providing insights into the pathological roles of OTUD3 in diseases such as cancer and neurodegenerative disorders.
The primary function of OTUD3 knockout cell lines is to facilitate the investigation of the gene's contribution to cellular functions and signaling pathways. The absence of OTUD3 leads to alterations in ubiquitination patterns with ramifications on critical cellular mechanisms, enabling scientists to probe the biological roles of this enzyme in a controlled environment. This capability is instrumental in elucidating the underpinnings of various diseases and can accelerate the development of targeted therapies.
From a scientific perspective, OTUD3 Gene Knockout Cell Lines are invaluable in both research and clinical settings. They serve as crucial tools for drug discovery, allowing for the screening of compounds that may restore proper cellular function. Moreover, these cell lines can be utilized for investigating the effects of OTUD3 modulation in pathological conditions, paving the way for therapeutic breakthroughs.
Compared to traditional knockdown methods, such as RNA interference, the gene knockout approach offers higher specificity and permanence of gene silencing, making OTUD3 knockouts a superior choice for long-term studies. This reliability also minimizes off-target effects, which are common pitfalls in transient knockdown experiments.
Researchers and clinicians will find that these cell lines are an essential resource for understanding the dynamic role of OTUD3 in cell biology and disease mechanisms. Their capacity to yield reproducible and interpretable results positions them as a fundamental tool in the arsenal of molecular biology.
At our company, we pride ourselves on our expertise in genetic engineering and cellular models. Our commitment to innovation and quality ensures that our OTUD3 Gene Knockout Cell Lines meet the highest standards, significantly aiding scientists in their quest to unravel the complexities of gene function and therapeutic interventions.
Please note that all services are for research use only. Not intended for any clinical use.
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