Gene: OSTM1
Official Full Name: osteoclastogenesis associated transmembrane protein 1provided by HGNC
Gene Summary: This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27299 | OSTM1 Knockout cell line (HeLa) | Human | OSTM1 | 1:3~1:6 | Negative | Online Inquiry |
KO27300 | OSTM1 Knockout cell line (HCT 116) | Human | OSTM1 | 1:2~1:4 | Negative | Online Inquiry |
KO27301 | OSTM1 Knockout cell line (HEK293) | Human | OSTM1 | 1:3~1:6 | Negative | Online Inquiry |
KO27302 | OSTM1 Knockout cell line (A549) | Human | OSTM1 | 1:3~1:4 | Negative | Online Inquiry |
OSTM1 Gene Knockout Cell Lines are a revolutionary tool designed for researchers seeking to investigate the functional roles of the OSTM1 gene and its implications in various biological processes. These genetically engineered cell lines are created using CRISPR/Cas9 technology, which enables precise editing of the OSTM1 gene, thereby facilitating the study of its absence on cellular physiology, signaling pathways, and disease mechanisms. The knockout of this gene allows scientists to explore the contributions of OSTM1 in cellular functions such as lysosomal biogenesis, autophagy, and its potential roles in metabolic and neurodegenerative diseases.
The uniqueness of OSTM1 Gene Knockout Cell Lines lies in their ability to mimic pathological states effectively, providing valuable insights into OSTM1-related conditions. These cell lines serve as a vital asset in both research and clinical settings, enabling scientists to conduct detailed functional assays, drug discovery efforts, and genetic studies that are critical for unraveling complex disease mechanisms. The importance of these tools extends to their application in therapeutic development and personal medicine, where understanding the genetic underpinnings of diseases can lead to innovative treatments.
Compared to conventional methods of gene silencing such as RNA interference, OSTM1 Gene Knockout Cell Lines offer a more stable and comprehensive approach to examine gene function, eliminating off-target effects that often compromise experimental validity. Additionally, these cell lines are readily available and can be utilized across various platforms, enhancing their accessibility for laboratories aiming to advance research in genetics, molecular biology, and pharmacology.
In summary, OSTM1 Gene Knockout Cell Lines represent an indispensable resource for researchers and clinicians dedicated to understanding the complexities of the OSTM1 gene and its associated pathways. Backed by our company's strong expertise in genetic engineering and cell line development, we are committed to providing high-quality, innovative biological products that facilitate groundbreaking research and foster advancements in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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