Gene: OR4K3
Official Full Name: olfactory receptor family 4 subfamily K member 3 (gene/pseudogene)provided by HGNC
Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15492 | OR4K3 Knockout cell line (HeLa) | Human | OR4K3 | 1:3~1:6 | Negative | Online Inquiry |
KO15493 | OR4K3 Knockout cell line (HCT 116) | Human | OR4K3 | 1:2~1:4 | Negative | Online Inquiry |
KO15494 | OR4K3 Knockout cell line (HEK293) | Human | OR4K3 | 1:3~1:6 | Negative | Online Inquiry |
KO15495 | OR4K3 Knockout cell line (A549) | Human | OR4K3 | 1:3~1:4 | Negative | Online Inquiry |
OR4K3 Gene Knockout Cell Lines are artificially engineered cellular models created to lack the functional expression of the OR4K3 gene, a member of the olfactory receptor gene family, which plays a significant role in various physiological processes, including sensory signaling and potential immune response functions. These knockout cell lines utilize CRISPR-Cas9 gene-editing technology, allowing researchers to study the gene's specific contributions to cellular behavior without interference from its normal expression.
Functionally, the OR4K3 Gene Knockout Cell Lines enable in-depth analysis of olfactory signaling pathways, providing insights into how variations in these pathways may impact both health and disease. Specifically, the absence of the OR4K3 receptor can alter how cells respond to specific stimuli, facilitating the identification of underlying mechanisms related to sensory perception and neuronal communication. This renders the knockout lines a valuable tool for hormone signaling studies, neurobiology research, and even pharmaceutical drug development.
The scientific importance of these cell lines is underscored by their potential applications in research environments focused on neurology, sensory disorders, and pharmacology. By eliminating the confounding variables linked to the presence of the OR4K3 gene, researchers can isolate specific effects and explore new therapeutic avenues with greater accuracy.
Compared to traditional wild-type cells or other gene knockout models, OR4K3 Gene Knockout Cell Lines offer distinct advantages, such as precise editing with minimal off-target effects and reproducibility in experimental settings. Their design enhances experimental rigor, ensuring that results are both consistent and scientifically valid.
For researchers and clinicians, this product stands as a pivotal resource, empowering them to advance knowledge in olfactory receptor biology and its intricate roles in human health. The continued innovation in our products reflects our commitment to providing unparalleled tools that exceed current research standards.
With extensive experience in developing cutting-edge biological products, our company is dedicated to facilitating groundbreaking scientific discoveries through precision-engineered solutions tailored for the modern research landscape.
Please note that all services are for research use only. Not intended for any clinical use.
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