Gene: OPHN1
Official Full Name: oligophrenin 1provided by HGNC
Gene Summary: This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36263 | OPHN1 Knockout cell line (HeLa) | Human | OPHN1 | 1:3~1:6 | Negative | Online Inquiry |
KO36264 | OPHN1 Knockout cell line (HCT 116) | Human | OPHN1 | 1:2~1:4 | Negative | Online Inquiry |
KO36265 | OPHN1 Knockout cell line (HEK293) | Human | OPHN1 | 1:3~1:6 | Negative | Online Inquiry |
KO36266 | OPHN1 Knockout cell line (A549) | Human | OPHN1 | 1:3~1:4 | Negative | Online Inquiry |
OPHN1 Gene Knockout Cell Lines are specialized, genetically engineered cell lines designed to facilitate the study of the OPHN1 gene, which plays a pivotal role in neuronal development and function. These cell lines have had the OPHN1 gene selectively inactivated, allowing researchers to investigate the gene's contributions to various biological processes and its implications in neurological disorders.
The primary function of OPHN1 Gene Knockout Cell Lines is to provide a model for examining the downstream effects of OPHN1 gene depletion on cellular mechanisms, such as synaptic function, neuronal signaling, and cell differentiation. By utilizing CRISPR-Cas9 technology, these cell lines exhibit precise knockout of the gene, enabling researchers to dissect the molecular pathways and physiological alterations that result from OPHN1 loss. This supports a deeper understanding of the gene's role in conditions like Intellectual Disability and other neurodevelopmental disorders.
The scientific importance of these cell lines lies in their broad applications; they serve as vital tools in basic research, drug discovery, and the development of gene therapies, particularly for diseases associated with OPHN1 dysfunction. Their use in research can lead to significant insights into disease mechanisms and therapeutic strategies, making them invaluable in both academic and clinical settings.
What sets these OPHN1 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability. Unlike other models that may exhibit variability or incomplete knockout efficiency, our cell lines ensure robust deletion of the OPHN1 gene, allowing consistent replication of study outcomes. They are extensively validated for use in high-throughput screening and other applications, yielding trustworthy data that can accelerate discovery.
For researchers and clinicians, the use of OPHN1 Gene Knockout Cell Lines can bridge the gap between genetic findings and clinical insights, ultimately advancing our understanding of complex neurological disorders. Their ability to mimic disease conditions while providing a controlled environment makes them a valuable asset in research labs focused on neurobiology.
Our company specializes in the development of advanced molecular tools and repositories of genetically modified cell lines, backed by a commitment to delivering high-quality research products tailored to meet the evolving needs of the scientific community. With our expertise and dedication to innovation, we empower researchers to explore new frontiers in biological science.
Please note that all services are for research use only. Not intended for any clinical use.
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