Gene: ODF2
Official Full Name: outer dense fiber of sperm tails 2provided by HGNC
Gene Summary: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36275 | ODF2 Knockout cell line (HeLa) | Human | ODF2 | 1:3~1:6 | Negative | Online Inquiry |
KO36276 | ODF2 Knockout cell line (HCT 116) | Human | ODF2 | 1:2~1:4 | Negative | Online Inquiry |
KO36277 | ODF2 Knockout cell line (HEK293) | Human | ODF2 | 1:3~1:6 | Negative | Online Inquiry |
KO36278 | ODF2 Knockout cell line (A549) | Human | ODF2 | 1:3~1:4 | Negative | Online Inquiry |
The ODF2 Gene Knockout Cell Lines are a valuable tool in the field of cellular and molecular biology, designed specifically to facilitate the exploration of the role and function of the ODF2 gene, which is implicated in various reproductive and diagnostic processes. These cell lines are generated using advanced CRISPR-Cas9 genome-editing technology, enabling precise targeting and disruption of the ODF2 gene. This knockout approach allows researchers to investigate the cellular pathways influenced by ODF2, effectively shedding light on its biological roles and potential links to pathologies.
By eliminating the ODF2 gene, these cell lines provide a unique platform for studying its contributions to cellular structure and function, particularly in relation to sperm tail assembly and motility. This is crucial in reproductive biology research, as the defects in ODF2 can result in male infertility and other reproductive complications. The utilization of these knockout cell lines supports high-throughput screening for potential therapeutic targets as well as the validation of gene function in various experimental contexts, making them integral for advancing our understanding of gene function and regulation.
One of the key advantages of the ODF2 Gene Knockout Cell Lines over traditional methods, such as siRNA knockdown, is their stability and persistence, allowing for long-term studies without the continuous requirement of transfection. Moreover, these cell lines facilitate reproducibility across various research settings, providing consistent data critical for comparative analysis.
Researchers and clinicians alike will find value in these cell lines for their potential applications in drug discovery and development, enabling the identification of novel strategies for treating infertility linked to ODF2 gene dysfunction. Additionally, the knockout design empowers scientists to elucidate genetic interactions and pathways, thereby advancing our overall understanding of both basic and clinical biological questions.
At [Company Name], we pride ourselves on pioneering innovative solutions that empower researchers. With our expertise in molecular biology and commitment to high-quality product offerings, we are dedicated to supporting the scientific community in unlocking the complexities of gene expression and regulation through our advanced tools and technologies.
Please note that all services are for research use only. Not intended for any clinical use.
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