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OBSL1 Knockout Cell Lines

Gene: OBSL1

Official Full Name: obscurin like cytoskeletal adaptor 1provided by HGNC

Gene Summary: Cytoskeletal adaptor proteins function in linking the internal cytoskeleton of cells to the cell membrane. This gene encodes a cytoskeletal adaptor protein, which is a member of the Unc-89/obscurin family. The protein contains multiple N- and C-terminal immunoglobulin (Ig)-like domains and a central fibronectin type 3 domain. Mutations in this gene cause 3M syndrome type 2. Alternatively spliced transcript variants encoding different isoforms have been found in this gene. [provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09323 OBSL1 Knockout cell line (HeLa) Human OBSL1 1:3~1:6 Negative Online Inquiry
KO09324 OBSL1 Knockout cell line (HCT 116) Human OBSL1 1:2~1:4 Negative Online Inquiry
KO09325 OBSL1 Knockout cell line (HEK293) Human OBSL1 1:3~1:6 Negative Online Inquiry
KO09326 OBSL1 Knockout cell line (A549) Human OBSL1 1:3~1:4 Negative Online Inquiry

Background

OBSL1 Gene Knockout Cell Lines are specialized cellular models engineered to have a targeted deletion of the OBSL1 gene, which encodes for the Obscurin-like 1 protein. This protein plays a pivotal role in the structural integrity of myofibrils and is essential for proper muscle function. The creation of these knockout cell lines allows researchers to investigate the precise biological functions of the OBSL1 gene and understand its implications in various myopathies and other diseases.

The key functionality of the OBSL1 Gene Knockout Cell Lines lies in their ability to mimic disease states by simulating the effects of gene loss on cellular processes. Researchers can utilize these cell lines to explore cellular signaling pathways, muscle regeneration, and the downstream effects of gene deficiency. Mechanistically, the elimination of OBSL1 can lead to alterations in sarcomere structure, muscle cell proliferation, and differentiation, making these models critical for elucidating the molecular basis of muscle-related pathologies.

In a scientific context, these knockout cell lines are invaluable tools for both basic and applied research. They serve as platforms for drug testing, gene therapy development, and investigation into the mechanisms of disease, particularly in muscle disorders. Their application extends to biopharmaceutical development, where understanding gene involvement can pave the way for targeted therapies.

Compared to alternative cellular models, OBSL1 Gene Knockout Cell Lines offer specificity and precision in gene disruption, minimizing off-target effects often associated with other gene-editing techniques. Their reliable reproduction of gene knockouts significantly enhances experimental reproducibility—key for advancing scientific knowledge.

For researchers and clinicians alike, the OBSL1 Gene Knockout Cell Lines present a unique opportunity to delve into genetic and phenotypic relationships, fueling innovation in therapeutic strategies. With access to these cell lines, users can bridge gaps in understanding rare diseases and develop novel treatments that can ultimately improve patient outcomes.

Leveraging years of expertise in genetic engineering and cellular biology, our company prides itself on delivering high-quality biological research tools, including the OBSL1 Gene Knockout Cell Lines, to facilitate groundbreaking discoveries in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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