Gene: OBSCN
Official Full Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFprovided by HGNC
Gene Summary: The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07198 | OBSCN Knockout cell line (HeLa) | Human | OBSCN | 1:3~1:6 | Negative | Online Inquiry |
KO07199 | OBSCN Knockout cell line (HCT 116) | Human | OBSCN | 1:2~1:4 | Negative | Online Inquiry |
KO07200 | OBSCN Knockout cell line (HEK293) | Human | OBSCN | 1:3~1:6 | Negative | Online Inquiry |
KO07201 | OBSCN Knockout cell line (A549) | Human | OBSCN | 1:3~1:4 | Negative | Online Inquiry |
OBSCN Gene Knockout Cell Lines are genetically modified cell lines that have had the OBSCN (Obscurin) gene selectively disrupted, allowing researchers to study the functional roles of this large protein in cellular processes. Obscurin is known to be involved in striated muscle structure and function by organizing and anchoring other proteins within striated muscle cells. The knockout of this gene provides a unique model to investigate the broadly impactful effects of obscurin loss on muscle integrity, signaling pathways, and overall cell physiology.
The key function of these knockout cell lines lies in their ability to elucidate the molecular mechanisms underlying muscle diseases and dysfunction. Researchers can utilize these cell lines to explore how the absence of obscurin affects cytoskeletal integrity, calcium signaling, and myofibril assembly. This provides significant insights into how disruptions in these processes contribute to various cardiomyopathies and skeletal muscle disorders.
In the scientific community, OBSCN Gene Knockout Cell Lines represent a valuable tool not only in fundamental research but also in preclinical studies aimed at developing therapeutic interventions targeting muscle-related diseases. Their use in drug discovery and testing can accelerate the understanding of muscle pathology and the efficacy of novel treatments.
One of the distinct advantages of these cell lines compared to traditional models is their specificity and relevance to human muscle pathophysiology. They allow researchers to perform high-throughput screening and pinpoint molecular interactions more effectively than standard non-targeted cell lines. Additionally, they come with a robust background of characterized alterations, ensuring reproducibility and reliability in experimental setups.
Overall, OBSCN Gene Knockout Cell Lines are an invaluable resource for researchers and clinicians striving to understand the intricacies of muscle biology and disease. They offer a cutting-edge platform for unveiling the role of obscurin and developing innovative therapeutic strategies. The expertise and commitment to quality from our team at [Company Name] ensure that our products are designed to meet the highest standards, empowering scientific advancements in this critical area of research.
Please note that all services are for research use only. Not intended for any clinical use.
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