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NXN Knockout Cell Lines

Gene: NXN

Official Full Name: nucleoredoxinprovided by HGNC

Gene Summary: This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15558 NXN Knockout cell line (HeLa) Human NXN 1:3~1:6 Negative Online Inquiry
KO15559 NXN Knockout cell line (HCT 116) Human NXN 1:2~1:4 Negative Online Inquiry
KO15560 NXN Knockout cell line (HEK293) Human NXN 1:3~1:6 Negative Online Inquiry
KO15561 NXN Knockout cell line (A549) Human NXN 1:3~1:4 Negative Online Inquiry

Background

NXN Gene Knockout Cell Lines are genetically engineered cell models designed to facilitate the study of the NADH-dependent dehydrogenase NXN (NAD(P)H Oxidase-1), which plays a crucial role in cellular oxidative stress responses. These versatile cell lines are constructed using CRISPR-Cas9 technology, enabling precise gene editing that results in the complete knockout of the NXN gene. This allows researchers to examine the protein's function and its implications in various biological processes, including cell survival, metabolism, and disease progression.

The key functions of the NXN Gene Knockout Cell Lines lie in their ability to mimic different pathophysiological states by elucidating the impact of NXN deficiency on cellular mechanisms. By providing a platform to study the altered metabolic pathways and signaling cascades outside the influence of NXN, researchers can gain valuable insights into the gene's role in oncogenesis, neurodegenerative diseases, and age-related conditions.

The scientific importance of these cell lines is particularly significant in research and clinical settings. Researchers can utilize these models to evaluate drug responses, metabolic changes, and the molecular underpinnings of diseases associated with oxidative stress. Furthermore, the knockout cell lines are essential in validating NXN as a potential therapeutic target, contributing to the development of novel interventions.

Compared to conventional cell lines, NXN Gene Knockout Cell Lines offer specific advantages such as the robustness of CRISPR-Cas9 technology, which ensures efficient and reliable gene editing. This precision not only enhances the reproducibility of experimental results but also accelerates the research timeline, enabling faster generation of findings that could lead to significant breakthroughs.

Incorporating NXN Gene Knockout Cell Lines into research studies is invaluable for scientists and clinicians pursuing innovative solutions for oxidative stress-related diseases. These models deepen the understanding of NXN's physiological roles, forging pathways to therapeutic advancements that may benefit patient outcomes.

Our company specializes in high-quality genetic engineering solutions backed by extensive expertise in molecular biology. We are committed to providing unparalleled support and resources to researchers seeking to advance their work with precision-engineered biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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