Gene: NUPR1
Official Full Name: nuclear protein 1, transcriptional regulatorprovided by HGNC
Gene Summary: Enables DNA binding activity and transcription coactivator activity. Involved in several processes, including negative regulation of programmed cell death; positive regulation of oxidative phosphorylation; and regulation of catabolic process. Acts upstream of or within negative regulation of cell cycle. Located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09740 | NUPR1 Knockout cell line (HeLa) | Human | NUPR1 | 1:3~1:6 | Negative | Online Inquiry |
KO09741 | NUPR1 Knockout cell line (HEK293) | Human | NUPR1 | 1:3~1:6 | Negative | Online Inquiry |
KO09742 | NUPR1 Knockout cell line (A549) | Human | NUPR1 | 1:3~1:4 | Negative | Online Inquiry |
NUPR1 Gene Knockout Cell Lines are advanced cellular models engineered to target and disrupt the NUPR1 gene, a critical regulator of cellular stress responses and oncogenesis. These cell lines are crafted using precise gene-editing technologies, such as CRISPR-Cas9, allowing researchers to study the functional consequences of NUPR1 loss on cell behavior, differentiation, and tumorigenesis. By providing a controlled environment devoid of NUPR1 expression, these knockout cell lines enable deeper insights into the gene's role in various biological processes, facilitating the examination of cellular pathways involved in cancer progression and therapy resistance.
The primary functions of these cell lines revolve around understanding the NUPR1 protein's involvement in the regulation of apoptosis, cell proliferation, and cellular adaptation to stressors like hypoxia and nutrient deprivation. In a laboratory setting, scientists can employ these knockout lines to model diseases associated with aberrant NUPR1 expression, including pancreatic cancer and other aggressive malignancies, thereby elucidating possible therapeutic targets and markers.
From a scientific standpoint, NUPR1 Gene Knockout Cell Lines are invaluable tools for cancer research and drug discovery. Researchers can leverage these models to assess the efficacy of novel chemotherapeutics and to investigate pathways that may contribute to tumor survival when NUPR1 is absent. Compared to conventional cell lines that retain endogenous NUPR1, these knockout models provide clearer interpretations of experimental outcomes and biologically relevant data.
A key advantage of our NUPR1 Gene Knockout Cell Lines is their meticulous validation and characterization, ensuring reliability and reproducibility across experiments. They are specifically designed for ease of use, with robust growth and maintenance characteristics that allow for rapid integration into research workflows. For researchers and clinicians invested in unveiling the complexities of cancer biology and developing effective treatment strategies, these cell lines offer a unique opportunity to push the boundaries of current knowledge.
Our company specializes in developing high-quality biological products, leveraging our deep expertise in gene editing and cell biology. We are committed to advancing research and clinical applications, and our NUPR1 Gene Knockout Cell Lines exemplify our dedication to providing innovative solutions that enhance scientific inquiry.
Please note that all services are for research use only. Not intended for any clinical use.
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