Gene: NUDT11
Official Full Name: nudix hydrolase 11provided by HGNC
Gene Summary: NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15591 | NUDT11 Knockout cell line (HEK293) | Human | NUDT11 | 1:3~1:6 | Negative | Online Inquiry |
KO15592 | NUDT11 Knockout cell line (A549) | Human | NUDT11 | 1:3~1:4 | Negative | Online Inquiry |
NUDT11 Gene Knockout Cell Lines are expertly developed cellular models that have undergone precise genetic engineering to disrupt the NUDT11 gene. This gene encodes a nucleotide diphosphate-linked moiety X (NUDT) protein that plays a pivotal role in cellular nucleotide metabolism, specifically in regulating the levels of nucleotide triphosphates and preventing the accumulation of potentially harmful metabolites. By generating NUDT11 knockout lines, researchers can examine the biological consequences of NUDT11 loss, offering insights into its functions in DNA repair, cellular stress response, and metabolic regulation.
These cell lines function primarily through the absence of NUDT11 protein, leading to alterations in nucleotide homeostasis that can trigger downstream effects on cellular growth, proliferation, and apoptosis. This knockout model is particularly valuable in studying diseases linked to nucleotide metabolism, such as certain genetic disorders and cancers, where NUDT11 may play a critical role. The engineered models allow for the examination of cellular pathways and drug responses in conditions mimicking human disease, offering a strong platform for research and therapeutic development.
The scientific importance of NUDT11 Gene Knockout Cell Lines extends to both basic and applied research, providing crucial tools for elucidating pathways involved in cell signaling, metabolism, and disease mechanisms. Unlike alternative models that may suffer from incomplete gene disruption, our knockout lines guarantee a reliable and consistent loss-of-function scenario, enabling reproducible results and higher confidence in experimental outcomes.
Researchers and clinicians will find great value in these cell lines, which provide opportunities for high-impact studies in drug discovery, toxicology, and the identification of novel therapeutic targets. Our commitment to quality and precision in genetic engineering ensures that our NUDT11 Gene Knockout Cell Lines meet the rigorous standards required for cutting-edge research applications.
With a dedication to advancing scientific knowledge, our company specializes in the production of high-quality genetic models and biological products, supporting the research community with tools that foster innovation and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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