Gene: NTRK3
Official Full Name: neurotrophic receptor tyrosine kinase 3provided by HGNC
Gene Summary: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08052 | NTRK3 Knockout cell line (A549) | Human | NTRK3 | 1:3~1:4 | Negative | Online Inquiry |
NTRK3 Gene Knockout Cell Lines are sophisticated biological tools designed for the study of neurotrophic receptor tyrosine kinase 3 (NTRK3) signaling pathways. These cell lines are engineered for the specific deletion of the NTRK3 gene, which encodes a key receptor involved in neuronal development, survival, and differentiation. By utilizing CRISPR-Cas9 technology, the NTRK3 Gene Knockout Cell Lines facilitate advanced exploration of cellular mechanisms underlying neurodevelopmental disorders and other pathologies associated with aberrant NTRK3 signaling.
The primary function of these knockout cell lines is to provide a controlled environment to observe the cellular responses in the absence of NTRK3. Researchers can employ these models to assess downstream signaling pathways, cellular proliferation, and apoptosis, ultimately contributing to a greater understanding of how NTRK3 influences neuronal function and health. Additionally, these cell lines may be used in therapeutic screening for drug candidates targeting NTRK3-related conditions, thus having lasting implications in precision medicine.
A significant advantage of NTRK3 Gene Knockout Cell Lines compared to similar products is their high specificity and complete gene disruption, which enhance experimental reproducibility and reliability. Furthermore, the availability of these models in multiple cellular contexts—such as primary neuronal cultures and various cancer cell lines—ensures versatility in experimental design tailored to specific research needs.
For researchers and clinicians, these cell lines offer invaluable insights into NTRK3's biological roles, paving the way for novel therapeutic strategies and interventions. The implications of this research extend to the fields of neurology, oncology, and developmental biology, making these knockout cell lines an essential asset in any laboratory focused on advancing their understanding of neurotrophic factors.
With a strong commitment to scientific excellence and innovation, our company specializes in the development of high-quality biological products such as NTRK3 Gene Knockout Cell Lines, equipping researchers with the tools needed to advance their investigations and foster breakthroughs in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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