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NRN1L Knockout Cell Lines

Gene: NRN1L

Official Full Name: neuritin 1 likeprovided by HGNC

Gene Summary: The protein encoded by this gene is extracellular and enhances both neurite growth and neuronal survival. The encoded protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. [provided by RefSeq, Feb 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28500 NRN1L Knockout cell line (HEK293) Human NRN1L 1:3~1:6 Negative Online Inquiry

Background

NRN1L Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the expression of the Neuritin 1-like (NRN1L) gene. These specialized cell lines enable researchers to investigate the role of NRN1L in various biological processes and disease models, particularly in neurobiology and oncology. By utilizing CRISPR/Cas9 gene-editing technology, NRN1L knockout lines facilitate the exploration of the gene's function in neuronal growth, synaptic plasticity, and response to stress, providing a valuable tool for elucidating its contribution to cellular signaling pathways and disease mechanisms.

The primary function of NRN1L knockout cells lies in their ability to serve as a comparative baseline for understanding the consequences of NRN1L absence. The disruption of NRN1L expression can lead to altered cellular behaviors, such as differentiation, apoptosis, and migration, which are crucial for both fundamental research and the development of therapeutic strategies. As an important player in neurodevelopmental disorders and certain cancers, examining these knockout cells allows for the insight needed to devise potential interventions or drug targets.

One of the unique advantages of NRN1L Gene Knockout Cell Lines is their specificity; the precise disruption of the NRN1L gene allows scientists to directly attribute observed phenotypic changes to the absence of this gene, unlike more general inhibitors or chemical agents that may elicit off-target effects. Additionally, these cell lines are compatible with various experimental techniques, including high-throughput screening, CRISPR validation, and gene expression studies, making them versatile tools for researchers across different fields.

For researchers and clinicians focused on improving our understanding of neural mechanisms or developing novel therapeutic approaches, NRN1L Gene Knockout Cell Lines represent an indispensable asset. They enhance our ability to delineate gene functions in health and disease, driving innovative research forward. Our company's commitment to excellence in genetic engineering and cell line development ensures that you receive high-quality, reliable products designed to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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