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NRCAM Knockout Cell Lines

Gene: NRCAM

Official Full Name: neuronal cell adhesion moleculeprovided by HGNC

Gene Summary: Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36317 NRCAM Knockout cell line (HeLa) Human NRCAM 1:3~1:6 Negative Online Inquiry
KO36318 NRCAM Knockout cell line (HEK293) Human NRCAM 1:3~1:6 Negative Online Inquiry
KO36319 NRCAM Knockout cell line (A549) Human NRCAM 1:3~1:4 Negative Online Inquiry

Background

NRCAM Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the neuronal cell adhesion molecule (NRCAM) and its implications in various biological processes. These cell lines are created through advanced genome editing techniques, such as CRISPR-Cas9, resulting in the absence of NRCAM expression. The key function of these knockout cell lines is to provide researchers with a platform to explore the role of NRCAM in neuronal development, synaptic function, and neurodegenerative diseases. By generating precise genetic alterations, these cell lines enable detailed analyses of signal transduction pathways and cellular interactions that are crucial for neuronal function.

The scientific importance of NRCAM Gene Knockout Cell Lines cannot be overstated, especially in research areas focusing on neurobiology and cellular adhesion mechanisms. These models serve as invaluable tools in elucidating the pathophysiology of conditions such as autism spectrum disorders and schizophrenia, where NRCAM has been implicated. In clinical settings, these cell lines can accelerate the development of novel therapeutic strategies by providing insights into disease mechanisms and potential targets for drug interventions.

What sets NRCAM Gene Knockout Cell Lines apart from other available cellular models is their specificity and the reliability of the gene knockout, which eliminates off-target effects and allows researchers to confidently attribute observed phenotypes to the absence of NRCAM. Furthermore, these cell lines are often validated with various assays, ensuring high reproducibility and consistency in experimental results.

For researchers and clinicians alike, the value of NRCAM Gene Knockout Cell Lines extends beyond mere experimental utility; they represent a crucial advancement in our ability to dissect complex biological questions, push the boundaries of neuroscience research, and contribute to progress in personalized medicine.

At our company, we pride ourselves on our commitment to advancing scientific research by providing high-quality, reliable biological tools that empower researchers in their quest for knowledge. Our expertise in genomic technologies allows us to deliver products like the NRCAM Gene Knockout Cell Lines, ensuring robust results in your studies.

Please note that all services are for research use only. Not intended for any clinical use.

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