Gene: NR4A3
Official Full Name: nuclear receptor subfamily 4 group A member 3provided by HGNC
Gene Summary: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34349 | NR4A3 Knockout cell line (HeLa) | Human | NR4A3 | 1:3~1:6 | Negative | Online Inquiry |
KO34350 | NR4A3 Knockout cell line (A549) | Human | NR4A3 | 1:3~1:4 | Negative | Online Inquiry |
NR4A3 Gene Knockout Cell Lines are genetically modified cell lines where the NR4A3 gene has been specifically disrupted, enabling researchers to study the biological functions and roles of this important nuclear receptor in various physiological and pathological processes. NR4A3, a member of the NR4A family of nuclear receptors, is implicated in diverse cellular functions, including cell proliferation, apoptosis, and inflammation. By creating knockout models, researchers gain invaluable insight into the pathways and mechanisms influenced by NR4A3, particularly its involvement in cancer, cardiovascular, and neurodegenerative diseases.
The NR4A3 knockout cell lines operate through the absence of NR4A3, providing a comparative backdrop for assessing gene expression and signal transduction pathways activated in normal conditions versus those lacking NR4A3 function. This disruption facilitates targeted studies into how NR4A3 regulates metabolic processes, influencing downstream effectors critical for cellular homeostasis and survival. Understanding these mechanisms can lead to the identification of novel therapeutic targets for treating various diseases where NR4A3 plays a significant role.
The scientific importance of these cell lines extends beyond basic research; they serve as powerful tools in drug discovery and development, particularly in screening compounds that modulate NR4A3-related pathways. Additionally, their utility in preclinical studies makes them essential for evaluating the efficacy and safety of therapeutic interventions targeting NR4A3.
What sets our NR4A3 Gene Knockout Cell Lines apart from other genetic models is our commitment to high fidelity and reproducibility. Every batch undergoes rigorous validation to ensure consistent gene knockout efficiency and phenotypic stability, which are crucial for obtaining reliable experimental results. These characteristics make them ideal for both academic and pharmaceutical research settings.
Choosing our NR4A3 Gene Knockout Cell Lines empowers researchers and clinicians with a reliable and versatile tool that can accelerate their discoveries in the field of molecular biology and therapeutic development. With years of expertise in gene editing technologies, our company is dedicated to providing high-quality biological products that meet the evolving demands of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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