Gene: NPRL3
Official Full Name: NPR3 like, GATOR1 complex subunitprovided by HGNC
Gene Summary: Predicted to enable GTPase activator activity. Involved in cellular response to amino acid starvation and negative regulation of TORC1 signaling. Part of GATOR1 complex. Is active in lysosomal membrane. Implicated in familial focal epilepsy with variable foci 3. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09173 | NPRL3 Knockout cell line (HeLa) | Human | NPRL3 | 1:3~1:6 | Negative | Online Inquiry |
KO09174 | NPRL3 Knockout cell line (HCT 116) | Human | NPRL3 | 1:2~1:4 | Negative | Online Inquiry |
KO09175 | NPRL3 Knockout cell line (HEK293) | Human | NPRL3 | 1:3~1:6 | Negative | Online Inquiry |
KO09176 | NPRL3 Knockout cell line (A549) | Human | NPRL3 | 1:3~1:4 | Negative | Online Inquiry |
NPRL3 Gene Knockout Cell Lines are genetically engineered cell cultures specifically designed to lack the NPRL3 gene, a crucial component associated with cellular metabolism and tumor suppression. Utilizing advanced CRISPR/Cas9 genome editing techniques, these cell lines enable researchers to study the precise role of NPRL3 in various biological processes, including cellular growth, stress response, and metabolic regulation.
The key function of NPRL3 involves its regulation of the mTOR (mechanistic target of rapamycin) signaling pathway, which is essential for cellular homeostasis and nutrient sensing. By knocking out the NPRL3 gene, researchers can investigate the downstream effects on mTOR signaling and understand how its dysregulation can contribute to diseases such as cancer and metabolic disorders. This targeted approach allows for clearer insights into gene function and cellular pathways that are often obscured in wild-type cells due to compensatory mechanisms.
From a scientific perspective, NPRL3 Gene Knockout Cell Lines are invaluable tools for both basic research and clinical applications. They provide a platform for drug screening, biomarker discovery, and the elucidation of disease mechanisms, facilitating a deeper understanding of complex cellular networks. Furthermore, these cell lines can be used in various applications such as validating therapeutic targets, assessing the efficacy of new compounds, or examining gene interactions in metabolic pathways.
The unique advantage of utilizing NPRL3 Gene Knockout Cell Lines lies in the specificity of the knockout. Unlike traditional methods that may elicit off-target effects, our product ensures precise gene editing, thereby streamlining experimental setups and enhancing data reliability. Researchers and clinicians will find these knockout cell lines particularly valuable given the increasing demand for reproducible and accurate models in biomedical research.
As a leader in genetic engineering and cell line development, our company is dedicated to providing innovative and high-quality products, ensuring that researchers have access to the best tools for exploration and discovery. By harnessing our expertise, users can elevate their research and clinical outcomes in pursuit of groundbreaking findings.
Please note that all services are for research use only. Not intended for any clinical use.
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