Gene: NPL
Official Full Name: N-acetylneuraminate pyruvate lyaseprovided by HGNC
Gene Summary: This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25846 | NPL Knockout cell line (HeLa) | Human | NPL | 1:3~1:6 | Negative | Online Inquiry |
KO25847 | NPL Knockout cell line (HEK293) | Human | NPL | 1:3~1:6 | Negative | Online Inquiry |
NPL Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to facilitate the study of gene function and expression by providing a controlled environment for the complete loss of function of target genes. This product utilizes CRISPR/Cas9 technology, allowing for precise and efficient modification of the genome by inducing double-strand breaks that are subsequently repaired through non-homologous end joining, leading to knockout mutations. The precision and reliability of this method ensure that researchers can obtain cell lines with the desired genomic alterations.
The primary function of NPL Gene Knockout Cell Lines is to enable researchers to explore the biological roles of specific genes, understand disease mechanisms, and validate potential therapeutic targets. These cell lines provide important models for studying various cellular processes such as signaling pathways, metabolic functions, and responses to treatments, making them invaluable in both fundamental research and drug development. Their application extends to various fields, including cancer research, developmental biology, and regenerative medicine.
One of the key advantages of the NPL Gene Knockout Cell Lines is their high specificity and reproducibility. Unlike previous gene-editing technologies, the CRISPR approach minimizes off-target effects and allows for comprehensive screening of large gene networks, making them superior to traditional methods like RNA interference or insertional mutagenesis. Additionally, these cell lines are readily accessible and come with extensive characterization data, ensuring that researchers can confidently utilize them in their studies.
For researchers and clinicians alike, the value of the NPL Gene Knockout Cell Lines lies in their ability to streamline experiments, reduce the time required for gene function elucidation, and ultimately enhance the translation of findings from bench to bedside. By delivering a reliable and efficient means of gene modification, these cell lines empower scientists to advance their understanding of complex biological systems and accelerate the development of novel therapeutic strategies.
Founded on a solid foundation of scientific expertise and dedication to advancing biological research, our company is committed to providing innovative tools like the NPL Gene Knockout Cell Lines that support the scientific community in its quest for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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