Gene: NMRAL1
Official Full Name: NmrA like redox sensor 1provided by HGNC
Gene Summary: This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15693 | NMRAL1 Knockout cell line (HeLa) | Human | NMRAL1 | 1:3~1:6 | Negative | Online Inquiry |
KO15694 | NMRAL1 Knockout cell line (HCT 116) | Human | NMRAL1 | 1:2~1:4 | Negative | Online Inquiry |
KO15695 | NMRAL1 Knockout cell line (HEK293) | Human | NMRAL1 | 1:3~1:6 | Negative | Online Inquiry |
KO15696 | NMRAL1 Knockout cell line (A549) | Human | NMRAL1 | 1:3~1:4 | Negative | Online Inquiry |
NMRAL1 Gene Knockout Cell Lines represent a sophisticated approach to studying gene function and cellular behavior by selectively disabling the NMRAL1 gene. NMRAL1 (Nuclear Receptor-Associated Gene 1) plays a critical role in regulating signaling pathways associated with inflammation and cellular stress responses. By creating knockout cell lines, researchers can investigate the biological effects and pathways involved when NMRAL1 is absent, providing insights into its role in various physiological and pathological processes.
The mechanism behind these cell lines relies on advanced CRISPR/Cas9 technology, which allows for precise gene editing. This method ensures the complete disruption of the NMRAL1 gene, enabling scientists to observe phenotypic changes, alterations in gene expression profiles, and shifts in signaling cascades. This comprehensive approach facilitates a deeper understanding of molecular interactions and mechanisms linked to diseases such as cancer, autoimmune disorders, and metabolic syndromes.
NMRAL1 Gene Knockout Cell Lines are scientifically significant, contributing to a range of applications from basic biological research to translational studies in clinical settings. They serve as vital tools for drug discovery, providing insights into potential therapeutic targets, and helping to elucidate disease mechanisms.
Compared to traditional knockout models, these engineered cell lines provide enhanced efficiency and reproducibility. They are also more cost-effective and time-efficient when generating homogenous cell populations for study, thus maximizing research productivity. Moreover, the use of CRISPR technology allows for a rapid turnaround time compared to earlier methodologies such as homologous recombination.
For researchers and clinicians, the value of NMRAL1 Gene Knockout Cell Lines lies in their potential to uncover novel biological mechanisms and therapeutic targets. With our extensive expertise in genetic engineering and cell line development, our company is dedicated to providing high-quality biological products that empower researchers and accelerate scientific discovery. Our commitment to innovation ensures that you have access to the best tools for advancing your research objectives.
Please note that all services are for research use only. Not intended for any clinical use.
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